Interleukin 3 - Wikipedia
Interleukin 3 is an interleukin, a type of biological signal that can improve the body's natural response to disease as part of the immune system. [10] In conjunction with other β common chain cytokines GM-CSF and IL-5 , IL-3 works to regulate the inflammatory response in order to clear pathogens by changing the abundance of various cell ...
Interleukin - StatPearls - NCBI Bookshelf - National Center for ...
Aug 22, 2022 · Interleukin-33 (IL-33) Mast cells and Th2 lymphocytes express IL-33 that acts on various innate and immune cells including dendritic cells and T and B lymphocytes. It mediates Th2 responses and therefore participates in the protection against parasites and type-I hypersensitivity reaction.
Interleukin 3 - an overview | ScienceDirect Topics
Interleukin-3 (IL-3) is a cytokine that binds to a receptor composed of IL-3Rα and βc subunits, stimulating the growth of various progenitor cells and promoting the survival of macrophages, mast cells, and megakaryocytes.
Interleukin-3 gets a fresh start in the brain | Genes & Immunity
Dec 8, 2023 · Using multiple murine models and human tissue, we have identified interleukin-3 (IL-3) as a molecular messenger between the central nervous and peripheral immune systems that shapes brain...
Interleukin-3 is a predictive marker for severity and outcome …
Feb 18, 2021 · In a prospective multicentric study, we identify IL-3 as an independent prognostic marker for the outcome during SARS-CoV-2 infections. Specifically, low plasma IL-3 levels is associated...
Interleukin 3 - an overview | ScienceDirect Topics
Interleukin-3 (IL-3) is a cytokine of the beta common family—including IL-5 and granulocyte macrophage colony-stimulating factor—which stimulates proliferation and differentiation of a range of hematopoietic cell types through interaction with the IL-3 receptor heterodimer (IL3-R).
IL-3: key orchestrator of inflammation - Frontiers
Jun 12, 2024 · Interleukin (IL)-3 has long been known for its hematopoietic properties. However, recent evidence has expanded our understanding of IL-3 function by identifying IL-3 as a critical orchestrator of inflammation in a wide array of diseases.
Interleukin-3 gets a fresh start in the brain - PMC
Using multiple murine models and human tissue, we have identified interleukin-3 (IL-3) as a molecular messenger between the central nervous and peripheral immune systems that shapes brain inflammation and is an emerging therapeutic target.
Interleukin-3 amplifies acute inflammation and is a potential ... - Science
Mar 13, 2015 · Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis. Using a mouse model of abdominal sepsis, we showed that innate response activator B cells produce IL-3, which induces myelopoiesis of Ly-6C high monocytes and neutrophils and fuels a cytokine storm.
We discovered that astrocyte-derived IL-3 instigates microglial immune reactivity, chemotaxis, and motility programing which enables microglial migration through the brain’s parenchyma towards...