Interleukin 18 - Wikipedia
WEBIL-18 is a proinflammatory cytokine that facilitates type 1 responses. Together with IL-12, it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS).
Interleukin-18: Biological properties and role in disease ... - PubMed
WEBInitially described as an interferon (IFN)γ-inducing factor, interleukin (IL)-18 is indeed involved in Th1 and NK cell activation, but also in Th2, IL-17-producing γδ T cells and macrophage activation.
Interleukin-18 cytokine in immunity, inflammation, and …
WEBAug 11, 2022 · Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes and mesenchymal cell.
Interleukin‐18: Biological properties and role in disease …
WEBDec 16, 2017 · There is now ample evidence for a role of IL ‐18 in various infectious, metabolic or inflammatory diseases such as influenza virus infection, atheroma, myocardial infarction, chronic obstructive pulmonary disease, or Crohn's disease.
Interleukin-18 in metabolism: From mice physiology to human …
WEBOct 12, 2022 · Interleukin-18 (IL-18) is a classical member of the IL-1 superfamily of cytokines. As IL-1β, IL-18 precursor is processed by inflammasome/caspase-1 into a mature and biologically active form.
Interleukin-18 in Health and Disease - PubMed
WEBFeb 2, 2019 · IL-18 demonstrates a unique function by binding to a specific receptor expressed on various types of cells. In this review article, we will focus on the unique features of IL-18 in health and disease in experimental animals and humans.
Frontiers | Interleukin-18 cytokine in immunity, inflammation, and ...
WEBJul 25, 2022 · Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes and mesenchymal cell.
The structure and binding mode of interleukin-18
WEBOct 5, 2003 · Interleukin-18 (IL-18), a cytokine formerly known as interferon-γ- (IFN-γ-) inducing factor, has pleiotropic immunoregulatory functions, including augmentation of IFN-γ production,...
Interleukins in cancer: from biology to therapy - Nature
WEBJun 3, 2021 · Interleukin-18. IL-18 therapy has shown little preclinical efficacy, potentially due to IL-18BP, a high-affinity IL-18 decoy receptor.
Interleukin 18 - an overview | ScienceDirect Topics
WEBInterleukin-18 is a member of the interleukin-1 family of cytokines with pro-inflammatory and tumor-suppressive properties. Its ability to potently enhance the production of interferon-γ indicates in particular the crucial function of interleukin-18 as an immunomodulatory molecule.