Biology of IL-21 and the IL-21 receptor - PubMed
Interleukin-21 (IL-21) is the newest member of the common gamma-chain family of cytokines, which includes IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15. Its private receptor, IL-21R, has been shown to activate the Janus kinase/signal transducers and activators of …
Interleukin-21: a double-edged sword with therapeutic potential
Apr 22, 2014 · Interleukin-21 (IL-21) is a pleiotropic cytokine with actions on a broad range of lymphoid, myeloid and epithelial cells. These actions include effects on proliferation, survival,...
IL-21 Signaling in Immunity - PMC - PubMed Central (PMC)
The functional receptor for IL-21 is composed of the IL-21 receptor (IL-21R) and the common cytokine receptor γ chain ( γ c), which is also a subunit of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15.
Interleukin-21, acting beyond the immunological synapse, …
Jul 26, 2022 · IL-21, a pleiotropic T cell-derived cytokine, is key to GC biology through incompletely understood mechanisms. By genetically restricting production and receipt of IL-21 in vivo, we reveal how its independent actions on T and B cells combine to regulate the GC.
Interleukin 21 and its receptor are involved in NK cell ... - Nature
Nov 2, 2000 · We have cloned a cytokine–receptor pair, interleukin-21 and IL21R, that both regulates the proliferation of mature B and T cells in response to activating stimuli, and mediates expansion of...
Interleukin-21 activates human natural killer cells and modulates …
IL-21-mediated effects on the expression of NK cell receptors. In mice, IL-21 has been shown to modulate the expression of several activating and inhibiting NK cell receptors on purified IL-2-cultured NK cells.
Interleukin-21: a modulator of lymphoid proliferation ... - Nature
Sep 1, 2005 · The receptor for the cytokine interleukin-21 (IL-21) contains the common cytokine-receptor γ-chain, so IL-21 is one of the cytokines that has its effects ablated in individuals with...
IL-21 and IL-21 receptor: a new cytokine pathway modulates ... - PubMed
Interleukin (IL)-21 is a new member of the type I cytokine superfamily. Although it is most homologous to IL-15, it has a unique receptor chain, IL-21R, that pairs with the gamma-common cytokine receptor chain.
Interleukin-21 Receptor - an overview | ScienceDirect Topics
IL-21 receptor (IL-21R) is a heterodimeric receptor, formed by IL-21R α-chain and the common γ-chain subunit, which also exists in IL-2, IL-4, IL-7, IL-9, IL-13 and IL-15 receptors, and is mutated in individuals with X-linked severe combined immunodeficiency (X-SCID) (Asao et al., 2001; From: Immunobiology, 2016
Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 ...
IL-21 is a class I cytokine that exerts pleiotropic effects on both innate and adaptive immune responses. It signals through a heterodimeric receptor complex consisting of the IL-21 receptor (IL-21R) and the common γ-chain. A hallmark of the class I cytokine receptors is the class I cytokine receptor signature motif (WSXWS). The exact role of ...
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