Results: Syk deficiency in murine dendritic cells resulted in the enhancement of LPS-induced IFNβ and IL-10 but suppression of pro-inflammatory cytokines (TNFα, IL-6). Deficiency of Syk enhanced the activity of PI3K and elevated the phosphorylation of PI3K and Akt, which in turn, lead to the phospho-inactivation of the downstream, central ...

c-Cbl 是一种E3泛素连接酶，可通过介导受体的泛素化和降解、受体偶联酪氨酸激酶（SYK）以及Wnt/β-catenin信号通路从而参与免疫调节。C-Cbl还可通过Toll样受体（TLR）刺激后负向调控IL-12的产生，在树突状细胞（DC）功能调节中发挥关键作用。

These findings demonstrated the negative regulatory effects of Syk on IFNβ and IL-10, and the essential role of Syk in TLR4-mediated immune responses, suggesting the immunomodulatory potential of Syk could be a novel target for intervening …

Zymosan is a particulate yeast preparation that elicits high levels of IL-2 and IL-10 from dendritic cells (DC) and engages multiple innate receptors, including the Syk-coupled receptor dectin-1 and the MyD88-coupled receptor TLR2. Here, we show …

May 5, 2016 · Syk was responsible for TREM-2-mediated inhibitory signaling in lung cancer while Syk inhibitor restrained the IL-10 production of TREM-2 + DC. Hence, we suggest that TREM-2 might act as a negative immune regulator in lung cancer.

May 5, 2010 · CaMK contributes to the activation of the calcium-dependent protein tyrosine kinase Pyk2 that can transmit signals to MAPKs and potentially IL10, and thus, we tested whether Pyk2 was activated in response to zymosan.

May 17, 2016 · Remarkably, IL-10 neutralizing antibody and Syk inhibitor both lowered the suppressive potential of TREM-2+DCs in T cell proliferation. Also, adoptive transfer of this TREM-2+DCs accelerated the tumor growth rather than jeopardized survival in lung cancer-bearing mice.

Feb 11, 2025 · We showed that Lactiplantibacillus plantarum OLL2712 (OLL2712) strongly induces interleukin (IL)-10 production in immune cells. Although beneficial effects of this strain have been observed in both mice and humans, the mechanisms underlying IL …

Mar 1, 2016 · These findings demonstrated the negative regulatory effects of Syk on IFNβ and IL-10, and the essential role of Syk in TLR4-mediated immune responses, suggesting that the immunomodulatory potential of Syk could be a novel target for intervening in the process of inflammatory immune responses.

The inability of TLR2 ligands in zymosan to couple to ERK may explain the Syk dependence of the IL-2 and IL-10 response in DC and emphasises the importance of Syk-coupled pattern recognition receptors such as dectin-1 in the detection of yeasts.