Interleukin 9 - Wikipedia
Interleukin 9, also known as IL-9, is a pleiotropic cytokine (cell signalling molecule) belonging to the group of interleukins. [5] IL-9 is produced by variety of cells like mast cells , NKT cells, Th2 , Th17 , Treg , ILC2 , and Th9 cells in different amounts.
IL-9: Function, Sources, and Detection - PubMed
IL-9 is a pleiotropic cytokine produced in different amounts by a wide variety of cells including mast cells, NKT cells, Th2, Th17, Treg, ILC2, and Th9 cells. Th9 cells are considered to be the main CD4+ T cells that produce IL-9.
Cellular sources and immune functions of interleukin-9
Sep 17, 2010 · Interleukin-9 (IL-9) activates a heterodimeric receptor that consists of the IL-9 receptor α-chain (IL-9Rα) and the γ-chain and promotes the cross-phosphorylation of Janus kinase 1 (JAK1) and...
A brief history of IL-9 - PubMed
Mar 15, 2011 · IL-9 was first described in the late 1980s as a member of a growing number of cytokines that had pleiotropic functions in the immune system. Although many biological functions have been attributed to IL-9, it remains an understudied cytokine.
A reappraisal of IL-9 in inflammation and cancer
IL-9 supports the survival and proliferation of both ILC2s and mast cells and stimulates their production of effector cytokines and mast cell proteases. IL-9 can also act on non-hematopoietic, such as epithelial cells and airway smooth muscle cells triggering mucus production and …
A Brief History of IL-9 - PMC - National Center for Biotechnology ...
Mar 3, 2011 · A resurgence of interest in IL-9 has been spurred by recent work demonstrating a role for IL-9 in regulating inflammatory immunity, and in defining the transcription factors that activate the Il9 gene in cells that most efficiently produce IL-9. In this review we summarize the characterization of IL-9 biological activities, highlight roles for ...
An Update on Interleukin-9: From Its Cellular Source and Signal ...
Apr 29, 2019 · Interleukin-9 (IL-9) is a pleiotropic cytokine and was primarily studied in the context of T helper 2 (T H 2)-associated immuno-pathological conditions such as asthma and parasitic infections.
Crosstalk between the Producers and Immune Targets of IL-9
Nov 18, 2020 · IL-9, initially termed P40, is a single chain glycoprotein with molecular weight between 32 and 39 kDa (1). Without N-linked glycosylation IL-9 is 14 kDa. IL-9 was first found to support the long-term growth of antigen-independent Th cell lines (1).
The World according to IL-9 | The Journal of Immunology
Jul 1, 2023 · Among the cytokines regulating immune cells, IL-9 has gained considerable attention for its ability to act on multiple cell types as a regulator of beneficial and pathologic immune responses. Yet, it is still not clearly defined how IL-9 impacts immune responses.
Locus of (IL-9) control: IL9 epigenetic regulation in cellular …
Jun 3, 2024 · Interleukin 9 (IL-9), first discovered in the 1980s, is a pleiotropic cytokine with roles in type 2 immunity, autoimmunity, antitumor immunity, and other cellular processes1. IL-9 has diverse...