Interleukin 7 (IL-7) is a protein [5] that in humans is encoded by the IL7 gene. [6] [7] [8] IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, [9] follicular dendritic cells, [10] hepatocytes, [11] neurons, and epithelial cells, [12] but is not produced by normal ...

Overview: IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind Type I cytokine receptors. It is produced by stromal cells and is required for development and homeostatic survival of lymphoid cells.

Nov 19, 2019 · In their Review, Barata, Durum and Seddon describe IL-7’s key homeostatic functions and how its dysregulation can lead to autoinflammatory disease and cancer.

Dec 1, 2021 · Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B cells, remains one of the most extensively studied cytokines. It ...

IL-7 signaling through the IL-7 receptor (IL-7R) plays a critical role in the survival of CD4 and CD8 double-negative (DN) thymocytes during early T-cell development. 1,4 DN thymocytes can be divided into four populations known as DN1 (CD44 + CD25 −), DN2 (CD44 + CD25 +), DN3 (CD44 − CD25 +) and DN4 (CD44 − CD25 −). 1,5 The development ...

Interleukin-7 (IL-7) is produced by stromal cells, keratinocytes, and epithelial cells in host tissues or tumors and exerts a wide range of immune effects mediated by the IL-7 receptor (IL-7R). IL-7 is primarily involved in regulating the ...

Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well as in B cell maturation through the activation of the IL-7 ...

Interleukin-7 (IL-7) is a biological compound that plays a role in maintaining the balance of T cells, specifically by promoting the growth of both naïve and memory T cells. It has shown potential as a treatment for HIV infection and lymphopenia after chemotherapy, with fewer side effects compared to IL-2 treatment.

Jun 1, 2002 · IL-7 can be identified within the thymus of 13-day murine embryos coincident with the first wave of thymocyte expansion.19 The production of IL-7 has been identified in a subset of MHC class II+ epithelial cells21 that also express SCF, another important growth factor for early thymocytes.92 Interestingly, SCF synergizes with IL-7 in thymocyte ...

Dec 2, 2021 · Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B cells, remains one of the most extensively studied cytokines. It plays a vital role in health maintenance and disease prevention, and the congenital deficiency of IL-7 signaling leads to profound immunodefici …