Interleukin 3 - Wikipedia
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. [3] [4] Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: after removal of the signal peptide sequence, the mature protein contains 133 amino acids in its polypeptide ...
Interleukin 3 - an overview | ScienceDirect Topics
Interleukin-3 (IL-3) is a cytokine that binds to a receptor composed of IL-3Rα and βc subunits, stimulating the growth of various progenitor cells and promoting the survival of macrophages, mast cells, and megakaryocytes. It is mainly produced by lymphoid cells and plays a role in responding to stress in vivo.
IL-3: key orchestrator of inflammation - Frontiers
Jun 12, 2024 · IL-3 plays an important role in bones by directly targeting both osteoblasts and osteoclasts. IL-3 promotes the differentiation of human mesenchymal stem cells into osteoblasts and stimulates the formation and the survival of mononuclear osteoclasts .
Interleukin - StatPearls - NCBI Bookshelf - National Center for ...
Aug 22, 2022 · Interleukin-3 (IL-3) T cells and stem cells make IL-3. It functions as a multilineage colony-stimulating factor. Interleukin-4 (IL-4) CD4+T cells (Th2) synthesize IL-4, and it acts on both B and T cells. It is a B-cell growth factor and causes IgE and IgG1 isotype selection.
Interleukin-3 gets a fresh start in the brain | Genes & Immunity
Dec 8, 2023 · Using multiple murine models and human tissue, we have identified interleukin-3 (IL-3) as a molecular messenger between the central nervous and peripheral immune systems that shapes brain...
Interleukin-3 in hematology and oncology: current state of
Interleukin (IL)-3 is a multipotent hematopoietic growth factor produced by activated T cells, monocytes/macrophages and stroma cells. The human IL-3 gene is located on chromosome 5 near segment 5q31. The high-affinity receptor for human IL …
Astrocytic interleukin-3 programs microglia and limits ... - Nature
Jul 14, 2021 · Astrocytes constitutively produce IL-3, which elicits transcriptional, morphological, and functional programming of microglia to endow them with an acute immune response program, enhanced...
IL-3: key orchestrator of inflammation - PubMed
Jun 13, 2024 · Here, we describe the cell-specific functions of IL-3 and summarize its role in diseases. We discuss the current treatments targeting IL-3 or its receptor, and highlight the potential and the limitations of targeting IL-3 in clinics.
We discovered that astrocyte-derived IL-3 instigates microglial immune reactivity, chemotaxis, and motility programing which enables microglial migration through the brain’s parenchyma towards...
IL-3 finds its home in the brain - Cell Press
Jul 11, 2023 · Interleukin-3 (IL-3) induces emergency hematopoiesis in settings of acute inflammation. In this issue of Immunity, Kiss et al. find that IL-3 derived from astrocytes and CD4+ T cells is a key regulatory cytokine of the central nervous system, and increased IL-3 signaling exacerbates neuroinflammation.
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