Interleukin 23 - Wikipedia
WEBInterleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit. [1] IL-23 is part of the IL-12 family of cytokines. [2] The functional receptor for IL-23 (the IL-23 receptor) consists of a heterodimer between IL-12Rβ1 and IL-23R. [3]
Interleukin-23: a key cytokine in inflammatory diseases
WEBInterleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, p19 and p40. The p40 subunit is shared with IL-12. IL-23 and IL-12 have different receptors and different effects.
Interleukin-23 receptor - Wikipedia
WEBThe interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the IL23R gene. [5] In complex with the interleukin-12 receptor β1 subunit , it is activated by the cytokine interleukin 23 (IL-23). [6] The IL23R mRNA is …
Interleukin-23: as a drug target for autoimmune inflammatory …
WEBTargeting of IL-23 or the IL-23 receptor or IL-23 axis is a potential therapeutic approach for autoimmune diseases including psoriasis, inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis.
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
WEBAug 22, 2014 · IL-23 has crucial roles in the pathogenesis of autoimmunity as it induces a cell population with a unique inflammatory gene signature that includes Il17a (which encodes IL-17A), Il17f, Il6,...
Decoding IL-23 Signaling Cascade for New Therapeutic …
WEBSep 7, 2020 · The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis, or rheumatoid arthritis.
IL-23 past, present, and future: a roadmap to advancing IL-23 …
WEBApr 14, 2024 · IL-23 plays an important role in the pathogenesis of psoriatic disease, in part, by contributing to recurrence of skin lesions and inducing enthesitis in PsO and PsA, respectively (20, 63, 90). Clinical data suggest that selective IL-23p19 subunit inhibitors are effective in psoriatic disease.
IL-12 and IL-23 cytokines: from discovery to targeted ... - Nature
WEBJun 29, 2015 · Discovery of the cytokine IL-23, which shares a common p40 subunit with IL-12, prompted efforts to clarify the relative contribution of these two cytokines in immune regulation.
Insights into IL-23 biology: From structure to function
WEBInterleukin (IL-)23 is a central cytokine controlling TH17 development. Overshooting IL-23 signaling contribute to autoimmune diseases. Moreover, GWAS studies have identified several SNPs within the IL-23 receptor, which are associated with autoimmune diseases.
IL-23 past, present, and future: a roadmap to advancing IL-23 …
WEBApr 15, 2024 · Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease.