The Roles of IL-22 and Its Receptor in the Regulation of …
Interleukin (IL)-22 is a potent mediator of inflammatory responses. The IL-22 receptor consists of the IL-22Rα and IL-10Rβ subunits. Previous studies have shown that IL-22Rα expression is …
Interleukin-22: immunobiology and pathology - PMC - PubMed …
IL-22 and its receptor have been described in the human upper GI tract, including the oral cavity, salivary glands, tonsils, stomach, and esophagus, where IL-22 expression has been …
IL-22: There is a gap in our knowledge - PMC
Interleukin-22 (IL-22) is a critical cytokine in modulating tissue responses during inflammation. IL-22 is upregulated in many chronic inflammatory diseases, making IL-22 biology a potentially …
IL-22 as a target for therapeutic intervention: Current knowledge …
Sep 1, 2023 · The receptor for IL-22 is a etero-dimer of IL-22R1 and IL-10R2 is present on non-immune cells like fibroblasts and epithelial cells. The cytokine IL-22 binds to its receptor and …
Therapeutic opportunities of the IL-22–IL-22R1 system
Dec 31, 2013 · Data obtained over the past few years indicate that the IL-22–IL-22 receptor subunit 1 (IL-22R1) system has a high potential clinical relevance in psoriasis, ulcerative colitis,...
Interleukin-22: a potential therapeutic target in atherosclerosis
Aug 13, 2021 · The binding of IL-22 to its receptor complex can trigger a diverse array of downstream signaling pathways, in particular the JAK/STAT, to induce the expression of …
Functional biology of the IL-22-IL-22R pathway in regulating ... - PubMed
The ligand-receptor distribution of IL-22-IL-22R permits immune cells to regulate responses of epithelial cells, endothelial cells, fibroblasts, and other tissue-resident stromal cells. This …
Interleukin 22 - an overview | ScienceDirect Topics
Oct 31, 2018 · Interleukin 22 (IL-22) is a cytokine secreted by immune cells that specifically acts on epithelial cells. It has been found to have both proinflammatory and anti-inflammatory roles …
The tissue protective functions of interleukin-22 can be decoupled …
Apr 13, 2021 · Interleukin-22 (IL-22) acts on epithelial cells to promote tissue protection and regeneration, but can also elicit pro-inflammatory effects, contributing to disease pathology. …
The role of IL-22 in intestinal health and disease - PMC
IL-22 is a pleiotropic cytokine that acts in the regulation of host defense, barrier function, and metabolism. This review is focused on its physiological role in mucosal tissues in health and …
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