Recent studies have solidified the importance of IL-12 cytokines in shaping innate and adaptive immune responses in cancer and identified multipronged roles for distinct IL-12 family members, ranging from effector to regulatory immune functions.

Oct 15, 2020 · Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable antitumor efficacy in preclinical models has yet to be replicated in humans.

Interleukin 12 (IL-12) seemed to represent the ideal candidate for tumor immunotherapy, due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities.

Oct 1, 2022 · In cancer treatment, IL-12 has been proven to control both innate (NK cell) and adaptive (cytotoxic T lymphocytes) immunities. In many animal models, the antitumor impact of IL-12 is considered a powerful evolving drug in cancer immunotherapy.

Sep 5, 2014 · Interleukin-12 (IL-12) regulates inflammation by linking innate and adaptive immune responses. Most of the IL-12-induced effects are mediated by the secretion of interferon - γ. IL-12 is a...

In this review, we discuss the role IL-12 and IL-23 plays in tumor biology from preclinical and clinical data. In particular, we discuss the mechanism by which IL-23 promotes tumor growth and metastases and how the IL-12/IL-23 axis of inflammation can be targeted for cancer therapy.

Methods: In this review, we describe the structural features of IL-12 family and their roles involved in cancer. Results: IL-12 has been demonstrated to regulate both innate (natural killer cells) and adaptive (cytotoxic T lymphocytes) immunities in cancer therapy.

Dec 17, 2024 · IL-12 is a powerful immunomodulator that dramatically affects the immune system’s response to cancer, making it an attractive cytokine for cancer treatment. Its pleiotropic effects allow it to remodel the immunosuppressive tumor microenvironment (TME), recruiting cytotoxic lymphocytes, encouraging them to infiltrate immunologically ‘cold ...

Interleukin-12 (IL-12) is a type I cytokine involved in both innate and adaptive immunity that stimulates T and natural killer cell activity and induces interferon gamma production. IL-12 has been identified as a potential immunotherapeutic component for combinatorial cancer treatments.

Aug 15, 2007 · Interleukin-12 (IL-12) is recognized as a master regulator of adaptive type 1, cell-mediated immunity, the critical pathway involved in protection against neoplasia and many viruses.