The ASTCT ICANS grading system is a consensus guideline based on expert opinion (3). It consists of a 10-point encephalopathy screening tool called ICE followed by evaluation of other domains including consciousness, motor symptoms, signs of raised ICP/ cerebral edema.

Immune effector cell-associated neurotoxicity syndrome (ICANS) is a serious complication of immunotherapy that can cause neurological symptoms and requires prompt diagnosis and management.

For patient with early fever (within 72 hrs) or signiicant comorbidities can consider early tocilizumab. Tocilizumab 8 mg/kg (Consider alternative agents after 2 doses) *No more than 3 doses in a 24 hr period or 4 doses in total. Dexamethasone (10 mg q12-24 hrs) with tocilizumab initial tocilizumab.

Sep 17, 2024 · Healthcare professionals use a grading system called the immune effector cell-associated encephalopathy (ICE) score, which ranges from 1 through 4, to describe the extent …

(IEC-Associated Neurotoxicity Syndrome) ICANS is “a disorder characterized by a pathologic process involving the central nervous system following any immune therapy that results in the activation or engagement of endogenous or infused T cells and/or other immune effector cells.

Feb 7, 2022 · Immune Effector Cell Encephalopathy (ICE) Score. Management of ICANS is based on the severity of the score and the concurrence of CRS. Management is supportive for grade 1 ICANS, and dexamethasone with rapid taper is given for grade ≥2 ICANS.

ICANS grade is determined by the most severe event (ICE or CAPD score, level of consciousness, seizures, motor findings, raised ICP/cerebral edema) not attributable to any other cause.

Mar 5, 2023 · The severity of ICANS can be graded according to a a number of systems developed most frequently that proposed by the American Society for Transplantation and Cellular Therapy (ASTCT) 4.

Here we report the consensus recommendations of that group and propose new definitions and grading for CRS and neurotoxicity that are objective, easy to apply, and ultimately more accurately categorize the severity of these toxicities.

CAR T-Cell Grading and Management: ICANS ICANSCAR T-Cell Grading and Management: ICANS