IRF8 - Wikipedia
WEBInterferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene.
IRF8: Mechanism of Action and Health Implications - PMC
WEBInterferon regulatory factor 8 (IRF8) is a transcription factor of the IRF protein family. IRF8 was originally identified as an essentialfactor for myeloid cell lineage commitment and differentiation.
IRF8 as durable architect of the microglial chromatin landscape
WEBSep 23, 2024 · IRF8 is an exceptionally relevant transcription factor during the development of microglial cells in embryos 1. However, its roles in microglial development soon after birth, in steady-state ...
IRF8 Gene - GeneCards | IRF8 Protein | IRF8 Antibody
WEBAug 6, 2024 · IRF8 (Interferon Regulatory Factor 8) is a Protein Coding gene. Diseases associated with IRF8 include Immunodeficiency 32A and Immunodeficiency 32B. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in Immune system.
IRFs: master regulators of signalling by Toll-like receptors and ...
WEBSep 1, 2006 · The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown...
Transcription-independent regulation of STING activation and …
WEBAug 16, 2022 · Here we show that interferon regulatory factor 8 (IRF8) is essential for efficient activation of STING-mediated innate immune responses in monocytes. This function of IRF8 is independent of...
Role of IRF8 in immune cells functions, protection against infections ...
WEBIRF8 deficiency in humans causes a severe primary immunodeficiency presenting as susceptibility to infections, complete or severe depletion of blood dendritic cells (DC) subsets, depletion of CD14 + and CD16 + monocytes and reduced numbers and impaired activity of NK cells.
IRF8: Mechanism of Action and Health Implications - PubMed
WEBAug 24, 2022 · Interferon regulatory factor 8 (IRF8) is a transcription factor of the IRF protein family. IRF8 was originally identified as an essentialfactor for myeloid cell lineage commitment and differentiation. Deletion of Irf8 leads to massive accumulation of CD11b + Gr1 + immature …
IRF8 interferon regulatory factor 8 [ (human)] - National Center for ...
WEBIRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes. Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer.
IRF8: Mechanism of Action and Health Implications - MDPI
WEBAug 24, 2022 · Interferon regulatory factor 8 (IRF8) is a transcription factor of the IRF protein family. IRF8 was originally identified as an essentialfactor for myeloid cell lineage commitment and differentiation.