Dec 25, 2024 · IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and Primary Immunodeficiency With Predisposition To Severe Viral Infection .

Dec 25, 2024 · Complete information for IRF7 gene (Protein Coding), Interferon Regulatory Factor 7, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Dec 25, 2024 · IRF9 (Interferon Regulatory Factor 9) is a Protein Coding gene. Diseases associated with IRF9 include Immunodeficiency 65 Viral Infections and Primary Immunodeficiency With Predisposition To Severe Viral Infection.

Dec 25, 2024 · The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of TICAM1 recruits IRF3 (PubMed:25636800). IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and …

Dec 25, 2024 · Upon binding to c-di-GMP, cUAMP or cGAMP, STING1 oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state (PubMed:22394562, 25636800 ...

Symbol Description Category UniProt ID GIFtS GC id Score; 1: IRF3: Interferon Regulatory Factor 3: Protein Coding: Q14653: 59: GC19M049659: 70.30: 2: TBK1: TANK ...

Dec 25, 2024 · IRF1 (Interferon Regulatory Factor 1) is a Protein Coding gene. Diseases associated with IRF1 include Immunodeficiency 117 and Gastric Cancer. Among its related pathways are Bacterial infections in CF airways and Overview of …

Dec 25, 2024 · The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies.

Dec 25, 2024 · The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments ...

Dec 25, 2024 · Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, 30842653).