Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It is a 15.5–16 kDa protein [5] that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity.

Aug 8, 2018 · IL-2 was discovered in 1976 as a T cell growth factor 1 that was present in the supernatant of mitogen-activated human T cells and was capable of supporting the long-term growth of T cells in...

Interleukin-2 (IL-2), a 15.5-kDa variably glycosylated globular protein, was first described as T cell growth factor (TCGF), a potent mitogen and growth regulator of T cells in vitro (1 – 6).

Feb 8, 2025 · The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes.

Dec 25, 2024 · IL2 (Interleukin 2) is a Protein Coding gene. Diseases associated with IL2 include Breast Cancer and Mycosis Fungoides. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and growth factor activity.

Nov 7, 2004 · The existence of interleukin (IL)-2 has been recognized for over 25 years, and it remains one of the most extensively studied cytokines. Here we present a broad overview of IL-2 history, functional activities, biological sources, regulation and applications to disease treatment.

Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway plays a pivotal role within these processes. The most striking functions of the IL-2 – IL-2R pathway are the differential induction of autoimmune responses and tolerance.

Interleukin 2 (IL-2) was one of the first cytokines to be discovered. However, the complex role of IL-2 and its receptor in the regulation of immune responses is only now emerging. This review explores the various signals triggered by IL-2 and discusses their …

Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3 …

Mar 17, 2025 · Explore the role of IL-2 in immune regulation, from receptor subunits and signaling pathways to its impact on T-cell growth and immune system balance. Interleukin-2 (IL-2) is a critical cytokine in the immune system, primarily influencing T-cell …