Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. [5] . In humans is encoded by the IDO1 gene. [6] . IDO is involved in tryptophan metabolism.

Aug 2, 2018 · Targeting IDO1 represents a therapeutic opportunity in cancer immunotherapy beyond checkpoint blockade or adoptive transfer of chimeric antigen receptor T cells. In this review, we discuss the function of the IDO1 pathway in …

Dec 22, 2021 · The main theory about the function of IDO1 is that Trp availability is locally reduced while bioactive metabolites such as Kyn are increased, which mediate immune regulation and immune tolerance involved in the pathological mechanisms of tumor immune escape.

Dec 25, 2024 · IDO1 (Indoleamine 2,3-Dioxygenase 1) is a Protein Coding gene. Diseases associated with IDO1 include Listeriosis and Eosinophilia-Myalgia Syndrome. Among its related pathways are superpathway of tryptophan utilization and NAD metabolism.

Mar 27, 2024 · It has been demonstrated that IDO1, a target of immune checkpoint inhibition, functions as an oncogene in the majority of human malignancies. IDO1’s function in human pan-cancers hasn’t been thoroughly studied, though. The Kaplan–Meier (K-M) and COX analyses were applied to the survival analysis.

Aug 17, 2020 · IDO1 has been shown to inhibit T cell activation and induce T regulatory cell development in vitro (11, 12). In vivo, IDO1 is best known for its immunoregulatory role in mediating tumor immune evasion (13–15).

Sep 23, 2020 · In-depth study of the biological function of IDO1 according to the expressing (tumor) cell can help to understand if and when IDO1 inhibition can play a role in cancer therapy.

Dec 14, 2017 · One such immune “braking” mechanism that has emerged with broadly useful appeal is mediated by the cytosolic enzyme indoleamine 2,3-dioxygenase-1 (IDO1), which acts in immunometabolism and inflammatory programming through its biochemical function in tryptophan catabolism (4, 5).

4 days ago · IDO1’s microglial pruning function appears to be mediated through the interferon (IFN) signaling pathway, and the behavioral changes induced by IDO1 knockdown in the ACC could be reversed by activating this pathway. Our findings revealed that microglial IDO1 in the ACC drives pain sensitization and anxiety in chronic migraine, highlighting ...

Apr 21, 2021 · Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme enzyme that catalyzes the oxidation of L-tryptophan. Functionally, IDO1 has played a pivotal role in cancer immune escape via catalyzing the initial step of the kynurenine pathway, and overexpression of IDO1 is also associated with poor prognosis in various cancers.