Heat shock protein 90kDa alpha (cytosolic), member A1
WEBThe gene, HSP90AA1, encodes the human stress-inducible 90-kDa heat shock protein alpha (Hsp90A). Complemented by the constitutively expressed paralog Hsp90B which shares over 85% amino acid sequence identity, Hsp90A expression is initiated when a cell experiences proteotoxic stress.
HSP90AA1 Gene - GeneCards | HS90A Protein | HS90A Antibody
WEBAug 6, 2024 · Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer …
Regulation and function of the human HSP90AA1 gene
WEBOct 1, 2015 · Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β isoform, despite high amino acid sequence identity between the two proteins.
HSP90AA1 heat shock protein 90 alpha family class A member 1
WEBHSP90AA1 promotes lymphatic metastasis of hypopharyngeal squamous cell carcinoma by regulating epithelial-mesenchymal transition. Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.
HSP90A inhibition promotes anti-tumor immunity by reversing
WEBJan 28, 2020 · Here, we report that HSP90A is a clinically actionable target for NANOG-mediated multi-aggressive properties of immune-edited tumor cells. Mechanistically, transcriptional induction of HSP90AA1...
The HSP90 Family: Structure, Regulation, Function, and …
WEBAug 29, 2018 · The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are involved in myriad cellular processes. Their distribution in various cellular compartments underlines their essential roles in cellular homeostasis.
Structural and functional complexity of HSP90 in cellular ... - Nature
WEBJul 31, 2023 · In normal cells, HSP90 is primarily a cytoplasmic protein with a small nuclear pool, whereas TRAP1 is mainly found in mitochondria and GRP94 in the endoplasmic reticulum 13, 16, 17, 18. Functional...
Heat shock protein-90alpha (Hsp90α) stabilizes hypoxia ... - Nature
WEBMar 4, 2021 · Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival. Article Open access 03 January 2024. Introduction.
The HSP90AA1 gene is involved in heat stress responses and its ...
WEBJul 1, 2024 · The HSP90AA1 gene is a key regulator of cell apoptosis and autophagy. Heat stress–induced HSP90AA1 expression helps to maintain cell survival by inhibiting cell apoptosis and increasing cell autophagy.
Plasma HSP90AA1 Predicts the Risk of Breast Cancer Onset and …
WEBMay 24, 2021 · Aim: We aimed to develop and validate a comprehensive nomogram containing pre-treatment plasma HSP90AA1 to predict the risk of breast cancer onset and metastasis. Methods: We assessed the expression of HSP90s in breast cancer patients using an online database.
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