Hirudin - Wikipedia
Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin, hirudin binds to and inhibits only the activated thrombin, with a specific activity on fibrinogen. [8] .
Pharmacological Activities and Mechanisms of Hirudin and Its ...
Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as “Shuizhi” in traditional Chinese medicine), is the strongest natural specific inhibitor of thrombin found so far.
Hirudin - an overview | ScienceDirect Topics
Hirudin is a single-chain 65-amino acid polypeptide (7,000 Da) that forms an irreversible 1:1 complex with thrombin. Hirudin interacts with both the fibrinogen-binding and catalytic sites of thrombin, completely inhibiting all procoagulant actions of thrombin.
Hirudin - an overview | ScienceDirect Topics
Hirudin forms a biomolecular complex with thrombin via its acidic C-terminus and thereby prevents the activity of thrombin. Hirudin has been produced synthetically and used in the treatment of deep vein thrombosis and for coronary angioplasty reparation.
Hirudin - an overview | ScienceDirect Topics
Hirudin, a coagulation inhibitor isolated from the salivary glands of the medicinal leech (Hirudo medicinalis), is a potent inhibitor of thrombin that, unlike heparin, acts independently of ATIII and inhibits clot-bound thrombin as well as fluid-phase thrombin. Hirudin does not require a cofactor and is not susceptible to neutralization by PF4.
Hirudin: Its Biology and Clinical Use - PubMed
Over a century has passed since the anticoagulant properties of hirudin were identified. Our understanding of this unique and promising 65 amino acid polypeptide has grown steadily, allowing clinical experience to be gained.
Hirudin in the Treatment of Chronic Kidney Disease - PMC
Natural hirudin is an active ingredient extracted from Hirudo medicinalis, which has been found to be the strongest natural specific inhibitor of thrombin. Evidence based on pharmacological data has shown that hirudin has important protective effects in CKD against diabetic nephrology, nephrotic syndrome, and renal interstitial fibrosis.
The direct thrombin inhibitor hirudin - PubMed
This review discusses the pharmacology and clinical applications of hirudin, a bivalent direct thrombin inhibitor (DTI).
Cell-free synthesis of the hirudin variant 1 of the blood-sucking …
Nov 13, 2020 · Hirudin is a secretory protein produced in the salivary gland cells of sanguivorous leeches of the genus Hirudo 1, 2 and one of the most effective natural thrombin inhibitors.
Pharmacological Activities and Mechanisms of Hirudin and Its ...
Apr 16, 2021 · Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as "Shuizhi" in traditional Chinese medicine), is the strongest natural specific inhibitor of thrombin found so far.