The role of HDAC3 and its inhibitors in regulation of ... - Nature
Apr 18, 2023 · HDAC3 is a specific and crucial member of the HDAC family. It is required for embryonic growth, development, and physiological function. The regulation of oxidative stress …
The critical roles of histone deacetylase 3 in the pathogenesis …
Jul 23, 2021 · Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various …
HDAC3 Gene - GeneCards | HDAC3 Protein | HDAC3 Antibody
Oct 2, 2024 · HDAC3 (Histone Deacetylase 3) is a Protein Coding gene. Diseases associated with HDAC3 include Lipodystrophy, Familial Partial, Type 5 and Retinoblastoma. Among its …
Frontiers | The role of HDAC3 in inflammation: mechanisms and ...
Jul 9, 2024 · This review provides an overview of the roles of HDAC3, a class I HDAC isoform, in modulating inflammatory responses and discusses the molecular mechanisms by which …
HDAC1/2/3 are major histone desuccinylases critical for promoter ...
Aug 15, 2023 · To test whether HDACs are broadly responsible for histone desuccinylation in mammalian cells, we compared the effect of TSA treatment on histone succinylation in HeLa, …
Histone deacetylase-3: Friend and foe of the brain - PMC
Jun 2, 2020 · In this review, we describe that histone deacetylase-3 (HDAC3) is a particularly crucial regulator of both neurodevelopment and neurodegeneration. In addition, HDAC3 …
HDAC3 is critical in tumor development and therapeutic …
Mar 17, 2023 · HDAC3 is one of the main targets of histone deacetylase (HDAC) inhibitors in clinical development as cancer therapies, yet the in vivo role of HDAC3 in solid tumors is …
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of …
Aug 11, 2023 · HDAC3 and HDAC8 have critical biological functions and represent highly sought-after therapeutic targets. Because histone deacetylases (HDACs) have a very conserved …
The HDAC3 enzymatic activity regulates skeletal muscle fuel …
Nov 14, 2018 · Histone deacetylase 3 (HDAC3) is a major HDAC, whose enzymatic activity is targeted by small molecule inhibitors for treating a variety of conditions. However, its …
HDAC3 - an overview | ScienceDirect Topics
HDAC3 is a Target Protein and a Key Mediator of Cell Signals. Like HDAC1 and HDAC2, HDAC3 is also phosphorylated in the C-terminal domain by the protein kinase CK2 [14, 25]. The …
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