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  1. Functional single-cell genomics of human cytomegalovirus …

    • Cas9 is an effective tool for making targeted disruptions in the cytomegalovirus genome. Targeting individual essential herpesvirus genes by CRISPR–Cas9 was shown to disrupt their expression directly and the… See more

    Genome-Wide Screens For Host Factors of HCMV

    Next, we carried out a pooled screen for host factors of HCMV infection by systematically … See more

    Nature
    The Lytic Cascade Resolved by Single-Cell Transcriptomics

    Our pooled screens provide a genome-scale picture of the factors involved in lytic HCMV infection, but placing them into biological pathways and linking them to a stage of th… See more

    Nature
    Host Perturbations Can Block, Slow Or Accelerate Infection

    We next conducted a series of Perturb-seq experiments exploring the effect of targeting host and viral factors on the viral life cycle. In contrast to the pooled screen, where phe… See more

    Nature
    Virus-Directed Perturbations Alter The Infection Trajectory

    Compared to host genes, targeting viral genes led to qualitatively different outcomes (Fig. 5d,e and Extended Data Fig. 6d). Expectedly, cells with virus-targeting s… See more

    Nature
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  1. Studies of Hcmv Genome
  2. Pathogenesis of human cytomegalovirus in the …

  3. Structural basis for genome packaging, retention, and …

    Jul 27, 2021 · How the human cytomegalovirus (HCMV) genome—the largest among human herpesviruses—is packaged, retained, and ejected remains unclear. We present the in situ structures of the symmetry-mismatched portal …

  4. Frontiers | Functional Profile of Human …

    Sep 3, 2020 · The human cytomegalovirus (HCMV), whose genome is 235 ± 1.9 kbp long, is a common herpesvirus. However, the functions of many of its genes are still unknown. HCMV is closely associated with various human diseases …

  5. Human cytomegalovirus genomics and transcriptomics …

    Jan 2, 2019 · The human cytomegalovirus (HCMV) genome was sequenced by hierarchical shotgun almost 30 years ago. Over these years, low and high passaged strains have been sequenced, improving, albeit still far from …

  6. Sequences of complete human cytomegalovirus genomes from …

  7. Genomic and Functional Characteristics of Human …

  8. Human Cytomegalovirus Genomes Sequenced Directly From …

  9. Human cytomegalovirus genome - PubMed

  10. Decoding Human Cytomegalovirus | Science - AAAS

    Nov 23, 2012 · The human cytomegalovirus (HCMV) genome was sequenced 20 years ago. However, like those of other complex viruses, our understanding of its protein coding potential is far from complete. We used ribosome profiling …