Next, we carried out a pooled screen for host factors of HCMV infection by systematically … See more

Our pooled screens provide a genome-scale picture of the factors involved in lytic HCMV infection, but placing them into biological pathways and linking them to a stage of th… See more

We next conducted a series of Perturb-seq experiments exploring the effect of targeting host and viral factors on the viral life cycle. In contrast to the pooled screen, where phe… See more

Compared to host genes, targeting viral genes led to qualitatively different outcomes (Fig. 5d,e and Extended Data Fig. 6d). Expectedly, cells with virus-targeting s… See more