Oct 9, 2023 · HLA typing is a medical test used to assess whether organ and blood marrow donors are suitably and safely matched to a transplant recipient.

Jan 31, 2021 · Human Leukocyte Antigen or HLA typing assesses HLA “match” between donors & recipients for solid organ & hematopoietic stem cell (HSC) transplantation.

Aug 21, 2024 · Live donors need an HLA typing test to see whether they can donate a kidney, liver, or stem cells to someone they know. In other cases, such as kidney, heart, liver, or lung donations, HLA typing happens on deceased donors before the organs are retrieved.

HLA typing is performed in multiwell plastic trays with each well containing a serum of known HLA specificity. Lymphocytes are plated in the well and incubated, and complement (rabbit serum as a source) is added to mediate the lysis of antibody-bound lymphocytes.

Jun 3, 2024 · This information will help you understand your human leukocyte (LUKE-oh-site) antigen (HLA) typing and stem cell harvesting (collection). You’re getting this information because you’re being tested to see if you’re a potential stem cell donor.

HLA typing became the most critical component of matching hematopoietic cells between donors and recipients to help avoid acute graft rejection and graft-versus-host disease (GVHD) and improve patient outcomes. 1

Three main processes are used to perform HLA typing. The first is the more conventional serological cytotoxicity method where tiny samples of lymphocytes (taken from from blood or spleen) are added to Terasaki plates.

One of the tests you will have before you go on the waiting list is HLA typing, also called tissue typing. This test identifies certain proteins in your blood called antigens. Antigens are markers on the cells in your body, which help your body, tell the difference between self and non-self.

4 days ago · HLA Typing for Stem Cell Transplantation. High-resolution molecular typing of class I HLA loci (HLA A, B, C) and some class II HLA loci (HLA DRB1 and DPB1) is recommended for all individuals receiving an allogeneic HSCT and their adult donors. Typing of other class II HLA loci may also be useful.

Comprehensive NGS typing includes all eleven major histocompatibility HLA genes: HLA-A, B, C, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, and DPB1. Every sample is concurrently typed by rSSO for all 11 HLA loci to corroborate NGS HLA types and to confirm homozygosity.