HDAC8 as a target in drug discovery: Function, structure and design
The overexpression of HDAC8 in DMD and the observed amelioration of disease progression with specific inhibitors indicate that HDAC8 represents a promising novel target for Duchenne muscular dystrophy.
HDAC8 gene - MedlinePlus
The HDAC8 gene provides instructions for making an enzyme called histone deacetylase 8. This enzyme is involved in regulating the structure and organization of chromosomes during cell division. Before cells divide, they must copy all of their chromosomes.
HDAC8 Gene - GeneCards | HDAC8 Protein | HDAC8 Antibody
Oct 2, 2024 · HDAC8 (Histone Deacetylase 8) is a Protein Coding gene. Diseases associated with HDAC8 include Cornelia De Lange Syndrome 5 and Cornelia De Lange Syndrome. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription).
Histone deacetylase 8 (HDAC8) and its inhibitors with ... - PubMed
Feb 15, 2019 · This review is concerned about the structural and positional aspects of HDAC8 in the HDAC family. It also covers the contributions of HDAC8 in the pathophysiological conditions, a preliminary discussion about the recent scenario of HDAC8 inhibitors.
HDAC8: a multifaceted target for therapeutic interventions
Jul 1, 2015 · Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and parasitic infections. It is a structurally well-characterized enzyme that also deacetylates nonhistone proteins.
HDAC8: A Promising Therapeutic Target for Acute Myeloid …
Sep 4, 2020 · Histone deacetylase 8 (HDAC8), a class I HDAC that modifies non-histone proteins such as p53, is highly expressed in different hematological neoplasms including a subtype of acute myeloid leukemia (AML) bearing inversion of chromosome 16 [inv (16)].
55869 - Gene ResultHDAC8 histone deacetylase 8 [ (human)]
Jun 6, 2024 · Histone deacetylase 8 inhibition suppresses mantle cell lymphoma viability while preserving natural killer cell function. HDAC8-dependent deacetylation of PKM2 directs nuclear localization and glycolysis to promote proliferation in hepatocellular carcinoma.
A selective HDAC8 inhibitor potentiates antitumor immunity
Treatment of hepatocellular carcinoma–bearing mice with the selective HDAC8 inhibitor resulted in increased infiltration of CD8 + T cells. Further, treatment with the HDAC8 inhibitor and immune checkpoint blockade led to enhanced control of tumors with no evidence of toxicity.
HDAC8-dependent deacetylation of PKM2 directs nuclear
Dec 5, 2020 · Here, we found that HDAC8 can directly bind and deacetylate to regulate PKM2 protein at K62 residue, which further deepens our understanding of HDAC8 in regulating glucose metabolism and...
Histone deacetylase 8 (HDAC8) is a class I histone dea-cetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disabili-ty, and parasitic infections. It is a structurally well-char-acterized enzyme that …
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