Histone deacetylase 2 - Wikipedia
Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene. [5] It belongs to the histone deacetylase class of enzymes responsible for the removal of acetyl groups from lysine residues at the N-terminal region of the core histones (H2A, H2B, H3, and H4).
Histone deacetylase - Wikipedia
Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH 3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. [2] . HDACs allow histones to wrap the DNA more tightly. [3] .
HDAC2: a critical factor in health and disease - PubMed
Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for immune responses and is often significantly overexpressed in solid tumors. Nevertheless, transformed cells lacking HDAC2 due to …
Histone deacetylase-2: A potential regulator and therapeutic …
HDAC2 is responsible for the deacetylation of the N-terminal of histone H3 and H4, leading to a more compacted chromatin structure and transcriptional gene silencing (16,17). HDAC2 participates in the genesis and development of renal, cardiovascular, neurological and lung disease (18–23).
HDAC2 Gene - GeneCards | HDAC2 Protein | HDAC2 Antibody
Oct 2, 2024 · HDAC2 (Histone Deacetylase 2) is a Protein Coding gene. Diseases associated with HDAC2 include Glioma Susceptibility 1 and Mood Disorder. Among its related pathways are RNA Polymerase I Promoter Opening and Constitutive Signaling by …
Histone deacetylase (HDAC) 1 and 2 complexes regulate both
Oct 2, 2018 · The most widely studied PTM, histone acetylation, neutralizes positively charged lysine residues in histone tails, decreasing nucleosomal affinity for DNA and is therefore associated with...
Histone deacetylase 2 selective inhibitors: A versatile ... - PubMed
The present review updates details on the structural features, physiological functions, and roles of HDAC2 in different types of cancer, emphasizing the challenges and status of the development of HDAC2 selective inhibitors against various types of cancer.
Human HDAC1 and HDAC2 function in the DNA-damage …
Aug 29, 2010 · DNA double-strand break (DSB) repair occurs within chromatin and can be modulated by chromatin-modifying enzymes. Here we identify the related human histone deacetylases HDAC1 and HDAC2 as two...
Histone deacetylase‑2: A potential regulator and therapeutic ... - PubMed
HDAC2 has emerged as a promising therapeutic target for liver disease by regulating gene transcription, chromatin remodeling, signal transduction and nuclear reprogramming, thus receiving attention from researchers and clinicians.
Harnessing the HDAC–histone deacetylase enzymes, inhibitors …
Jun 10, 2019 · Histone deacetylase inhibitors (HDACis) can inhibit these enzymes, resulting in the increased acetylation of histones, thereby affecting gene expression. There is strong evidence to suggest that...