It is set in an early 20th century aristocratic hotel during the reign of Alfonso XIII and is centered on the mysteries that involve the owner's family and the hotel servants. The events take place in 1906–1907 in Spain, near a town called Cantaloa.

A family-owned hotel in the fictional coastal Spanish town of Cantaloa in 1905: love, blackmail, jealousies, crime, comedy, and plots and counter-plots all involving the hotel's owners, guests, detectives, and residential employees.

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Το «Grand Hotel» έχει λαμπερά εγκαίνια και ανοίγει τις πόρτες του. Η νέα δραματική σειρά του ΑΝΤ1 προβάλλεται από Δευτέρα έως Πέμπτη στις 21:00 και μας μεταφέρει στους μυστηριώδεις διαδρόμους του πολυτελούς ξενοδοχείου εκεί όπου θύματα και θύτες μπερδεύονται σε έναν κυκεώνα μυστικών, ψεμάτων και τραυματικών γεγονότων του παρελθόντος…

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Julio Olmedo travels to the Grand Hotel to visit his sister who works there as a maid. He discovers that she is missing and begins investigating her disappearance. Julio finds Cristina's blood-soaked uniform disposed of by Diego, he vows to Alicia he must find out the truth.

Grand Hotel is an American mystery drama television series developed by Brian Tanen, based on the Spanish television series Gran Hotel created by Ramón Campos and Gema R. Neira.