Glycosphingolipids - Essentials of Glycobiology - NCBI Bookshelf
This chapter describes the characteristic features of GSLs, pathways for their biosynthesis, and insights into their biological roles in membrane structure, host–pathogen interactions, cell–cell recognition, and modulation of membrane protein function.
Glycosphingolipids: Structure, Metabolism, Functions, Analytical ...
Glycosphingolipids are a class of complex lipids characterized by their unique structure, which integrates a ceramide backbone with one or more carbohydrate units. This structure is critical for their diverse functions in cellular membranes and biological processes.
Glycosphingolipids: synthesis and functions - D'Angelo - 2013
Oct 6, 2013 · In vertebrates, the most represented class of glycolipids is that of glycosphingolipids (GSLs) [7]. These are a heterogeneous class of amphipathic compounds that are characterized by complex glycan structures linked to a ceramide backbone by a β-glycosidic bond.
Structure and function of glycosphingolipids and sphingolipids ...
Based on development of various methodologies for isolation and characterization of glycosphingolipids (GSLs), we have identified a number of GSLs with globo-series or lacto-series structure. Many of them are tumor-associated or developmentally-regulated antigens.
Glycosphingolipids - SpringerLink
Sep 9, 2021 · Glycosphingolipids are amphiphilic plasma membrane components formed by a glycan linked to a specific lipid moiety. In this chapter we report on these compounds, on their role played in our cells to maintain the correct cell biology.
Glycosphingolipid - an overview | ScienceDirect Topics
Abstract. Glycosphingolipids are ubiquitous membrane components that play important roles in signal transduction events thereby affecting many cellular functions, including modulation of the immune response.
Glycosphingolipids: synthesis and functions - PubMed
Glycosphingolipids (GSLs) comprise a heterogeneous group of membrane lipids formed by a ceramide backbone covalently linked to a glycan moiety. Hundreds of different glycans can be linked to tens of different ceramide molecules, giving rise to an astonishing variety of structurally different compoun ….
Metabolism of Glycosphingolipids and Their Role in the …
Glycosphingolipid Structures. Among the simplest GSLs are Galβ-ceramide (GalCer) and Glcβ-ceramide (GlcCer), which are both highly abundant in the vertebrate brain (Figure 1 A–E). Further processing of GalCer and GlcCer can involve the addition of neutral or acidic sugars.
Ceramide structure dictates glycosphingolipid nanodomain assembly and ...
Jun 16, 2021 · Thus, different ceramide species of GM1 gangliosides dictate their assembly into nanodomains and affect nanodomain structure and function, which likely underlies many endogenous cellular...
STRUCTURE, FUNCTION AND METABOLISM OF GLYCOSPHINGOLIPIDS
Jan 1, 1980 · This chapter discusses the chemical structure, physical functions, and metabolism of glycosphingolipids. Neutral glycosphingolipids based on glucocerebrosides are in higher concentrations in non-neuronal tissue than in the neuronal tissue.
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