Genotoxicity - Wikipedia
Genotoxicity is the property of chemical agents that damage the genetic information within a cell causing mutations, which may lead to cancer. While genotoxicity is often confused with mutagenicity, all mutagens are genotoxic, but some genotoxic substances are not mutagenic.
Genotoxicity: damage to DNA and its consequences - PubMed
A genotoxin is a chemical or agent that can cause DNA or chromosomal damage. Such damage in a germ cell has the potential to cause a heritable altered trait (germline mutation). DNA damage in a somatic cell may result in a somatic mutation, which may lead to …
The various aspects of genetic and epigenetic toxicology: testing ...
May 22, 2017 · Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a …
Genotoxicity: damage to DNA and its consequences
A genotoxin is a chemical or agent that can cause DNA or chromosomal damage. Such damage in a germ cell has the potential to cause a heritable altered trait (germline mutation). DNA damage in a somatic cell may result in a somatic mutation, which may lead to …
Genotoxicity - an overview | ScienceDirect Topics
Genotoxicity is the ability of chemicals to damage the genetic information within a cell resulting in mutations, which may lead to malignancies. The genotoxic substances induce damage to the genetic material in the cells through interactions with the DNA sequence and structure.
Genotoxic risk assessment and mechanism of DNA damage …
Jan 18, 2021 · The human genome is persistently exposed to damage caused by xenobiotics, therefore the assessment of genotoxicity of substances having a direct contact with humans is of importance.
Genotoxicity - an overview | ScienceDirect Topics
Genotoxicity is referred to as the ability of a physical or chemical agent to cause DNA damage, which results in a mutation. It is one of the most crucial endpoints of toxicology studies and helps in screening the preliminary potential hazards of any chemical or drug.
A genotoxin is a chemical or agent that can cause DNA or chromosomal damage. Such damage in a germ cell has the potential to cause a heritable altered trait (germline muta-tion). DNA damage in a somatic cell may result in a somatic mutation, which may lead to malignant transformation (cancer).
Genotoxicity: Damage to DNA and Its Consequences
The targets of topical genotoxic agents are basal and stem cells of the skin. These cells may misrepair DNA lesions, resulting in deleterious mutations of tumor suppressors or oncogenes. However, the genotoxicity of many compounds has not as …
Genotoxicity - SpringerLink
The genotoxic or mutagenic potential is what we call the potential health risk of a substance with respect to its ability to cause cell mutations. Substances with this potential are known as mutagens and genotoxicity studies, also called mutagenicity …