GSTP1 - Wikipedia
The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
GSTP1 Gene - GeneCards | GSTP1 Protein | GSTP1 Antibody
Oct 2, 2024 · GSTP1 (Glutathione S-Transferase Pi 1) is a Protein Coding gene. Diseases associated with GSTP1 include Kala-Azar 2 and Hepatocellular Adenoma. Among its related pathways are Metapathway biotransformation Phase I and II and Innate Immune System.
Glutathione S-transferases P1 protects breast cancer cell from …
Jan 25, 2019 · Glutathione S-transferases P1 (GSTP1) is a phase II detoxifying enzyme and increased expression of GSTP1 has been linked with acquired resistance to anti-cancer drugs.
GSTP1 - an overview | ScienceDirect Topics
The GSTP1 gene, encoding the pi class glutathione S-transferase, was the first hypermethylated gene to be characterized in prostate cancer. GSTP1 is thought to protect prostate epithelial cells from carcinogen-associated and\or oxidative stress-induced DNA damage, and loss of GSTP1 may render prostate cells unprotected from such genomic insults.
GSTP1 and cancer: Expression, methylation, polymorphisms and signaling ...
Glutathione S‑transferase Pi (GSTP1) is an isozyme encoded by the GST pi gene that plays an important regulatory role in detoxification, anti‑oxidative damage, and the occurrence of various diseases. The aim of the present study was to review the association between the expression of GSTP1 and the d ….
GSTP1 glutathione S-transferase pi 1 [ (human)] - National Center …
The results suggest that the GSTP1 gene polymorphism is associated with an increased risk of osteosarcoma. we genotyped five hormone-related genes: estrogen receptor-alpha (ESR1), aromatase (CYP19), catechol-O-methyl transferase (COMT), sex hormone-binding globulin (SHBG)and glutathione S-transferase (GSTP1).
Glutathione transferases: substrates, inihibitors and pro-drugs …
Jan 24, 2018 · Monomeric GSTP1 protects tumoral cells from apoptosis by inhibition of the JNK signaling pathway through the formation of a GSTP1-JNK-cJun complex that hampers c-Jun phosphorilation.
Glutathione transferases as mediators of signaling pathways involved …
Jul 2, 2010 · This review is focused on the inhibition of GSTs, in particular GSTP1-1, as a potential therapeutic approach for the treatment of cancer and other diseases associated with aberrant cell...
GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell ... - Cell Press
May 19, 2016 · Using a reactivity-based chemoproteomic platform, Louie et al. have identified GSTP1 as a triple-negative breast cancer target that, when inhibited, impairs breast cancer pathogenicity through inhibiting GAPDH activity and downstream metabolism and …
Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine …
Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione ...