Oct 29, 2024 · Foscarnet is an antiviral agent used to treat cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella-zoster virus (VZV) infections, particularly in immunocompromised individuals. Foscarnet is typically reserved for viral strains for which first-line treatments may be less effective.

Foscarnet is principally used for the treatment of ganciclovir-resistant cytomegalovirus (CMV) infections in patients with acquired immunodeficiency syndrome (AIDS) or in transplant recipients. The mechanisms of action, pharmacokinetics, and adverse effects will be reviewed here.

Foscarnet is a structural mimic of the anion pyrophosphate that selectively inhibits the pyrophosphate binding site on viral DNA polymerases at concentrations that do not affect human DNA polymerases.

Mechanism of action. Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases.

Foscarnet is a pyrophosphate analogue that has antiviral activity against the herpes viruses, HIV, and hepatitis B virus. Its mechanism of action is interference with DNA polymerase or reverse transcriptase to block effective viral replication.

Jun 9, 2021 · Mechanism of Action - Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect ...

Oct 29, 2024 · Foscarnet is typically reserved for viral strains for which first-line treatments may be less effective. This activity examines the drug's mechanism of action, contraindications, adverse effects, and the FDA's boxed warnings.

Feb 17, 2020 · IV: Foscarnet is administered by intravenous infusion, using an infusion pump, at a rate not exceeding 1 mg/kg/minute. Adult induction doses of 60 mg/kg are administered over 1 hour. Adult maintenance doses of 90 to 120 mg/kg are infused over 2 hours.

Feb 14, 1992 · Current evidence indicates that foscarnet interferes with exchange of pyrophosphate from deoxynucleoside triphosphate during viral replication by binding to a site on the herpesvirus DNA polymerase or HIV reverse transcriptase.

Foscarnet and its analogues achieve their antiviral effects via inhibition of pesviruses and the reverse transcriptase of human immunodeficiency virus 1 (HIV-l). Foscarnet is a. teins. Current evidence indicates that foscarnet interferes with exchange …