Flucytosine: Uses, Interactions, Mechanism of Action - DrugBank …
Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms.
Flucytosine - Wikipedia
Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication. [2] It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis. [2] It may be used by itself or with other antifungals for chromomycosis. [2] Flucytosine is used by mouth and by injection into a vein. [2] [3]
Flucytosine Uses, Side Effects & Warnings - Drugs.com
Feb 29, 2024 · Flucytosine is an antifungal medication that fights infections caused by fungus. Flucytosine is used to treat serious fungal infections of the blood, lungs, heart, central nervous system, and urinary tract.
(flucytosine) dosing, indications, interactions, adverse effects, and …
Medscape - Indication-specific dosing for (flucytosine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information....
Flucytosine - StatPearls - NCBI Bookshelf
Feb 28, 2024 · Flucytosine, an antimetabolite within the antifungal drug class, addresses systemic and severe candida and cryptococcus infections. Operating exclusively within fungal cells, this medication spares mammalian cells, enhancing its safety profile.
Flucytosine (oral route) - Mayo Clinic
Flucytosine is used in combination with other medicine (eg, amphotericin B) to treat serious fungus infections, including Candida infections (eg, septicemia, endocarditis, urinary tract infections) or Cryptococcus infections (eg, meningitis, lung infections). This medicine works by killing the fungus or preventing its growth.
Flucytosine and its clinical usage - PMC - PubMed Central (PMC)
Flucytosine is an antifungal agent first licensed in the 1970’s. However, its clinical value has long been overlooked and its availability across the globe is limited. This review highlights the important clinical and pharmacological aspects of flucytosine.
Pharmacology of flucytosine (5-FC) - UpToDate
Jun 20, 2024 · Flucytosine (5-fluorocytosine, 5-FC) is an antifungal agent originally developed in 1957 as an antimetabolite. Although it has found no role as an anti-tumor agent, it is used for the treatment of certain fungal infections.
Flucytosine Monograph for Professionals - Drugs.com
Jun 10, 2024 · For treatment of urinary tract infections caused by Candida, especially fluconazole-resistant strains, oral flucytosine is used alone or in conjunction with IV amphotericin B. IDSA states antifungal treatment not usually indicated in patients with asymptomatic cystitis, unless there is high risk of disseminated candidiasis (e.g., neutropenic pat...
Flucytosine: Dosage, Mechanism/Onset of Action, Half-Life
Feb 9, 2020 · Includes Flucytosine indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more.