FAT4 Gene - GeneCards | FAT4 Protein | FAT4 Antibody
Oct 2, 2024 · GeneCards Summary for FAT4 Gene. FAT4 (FAT Atypical Cadherin 4) is a Protein Coding gene. Diseases associated with FAT4 include Van Maldergem Syndrome 2 and Hennekam Lymphangiectasia-Lymphedema Syndrome 2. Among its related pathways are Kidney development and GDNF signaling.
FAT4 - Wikipedia
Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene. [5] [6] FAT4 is associated with the Hippo signaling pathway. [7]
FAT4 overexpression promotes antitumor immunity by regulating …
Sep 1, 2023 · FAT4 (FAT Atypical Cadherin 4) is a member of the cadherin-associated protein family, which has been shown to function as a tumor suppressor by inhibiting proliferation and metastasis. The Wnt/β-catenin pathway activation is highly associated with PD-L1-associated tumor immune escape.
FAT4 gene - MedlinePlus
The FAT4 gene provides instructions for making a protein that is found in most tissues. The protein spans the membrane surrounding cells so that part of the protein is outside the cell and part of the protein is inside the cell.
FAT4 overexpression promotes antitumor immunity by regulating …
Sep 1, 2023 · We found that FAT4 overexpression promotes aberrant PD-L1 glycosylation and degradation in a β-catenin-dependent manner, thereby increasing cytotoxic T lymphocyte (CTL) activity in immunoreactive mouse models.
FAT4 functions as a tumour suppressor in gastric cancer by
Dec 3, 2015 · FAT4 has a tumour suppressor role mediated by the modulation of Wnt/β-catenin signalling, providing potential novel targets for the treatment of gastric cancer.
FAT4 expression in peripheral blood mononuclear cells is …
Sep 21, 2023 · On investigating the function of FAT4 in HCC, we found that FAT4 was primarily involved in biological processes related to cell motility and that FAT4 expression was significantly positively...
FAT4 regulates the EMT and autophagy in colorectal cancer
Mar 4, 2019 · FAT4 can regulate the activity of PI3K to promote autophagy and inhibit the EMT in part through the PI3K/AKT/mTOR and PI3K/AKT/GSK-3β signaling pathways.
FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling …
FAT4 mutations occur in humans with kidney disease. Controlling RET tyrosine kinase activity is critical for normal kidney development. Zhang et al. show that FAT4 restricts RET signaling activity by binding to RET and reducing RET interactions with its ligand GDNF-GFRA1. Thus, FAT4 loss leads to hyperactive RET signaling and disease.
Loss of Fat4 disrupts PCP signaling and oriented cell division …
Jul 6, 2008 · Here we show that Fat4 is an essential gene that has a key role in vertebrate PCP. Loss of Fat4 disrupts oriented cell divisions and tubule elongation during kidney development, leading to...
FAT4 FAT atypical cadherin 4 [ Homo sapiens (human) ]
Title: Increased expression of FAT4 suppress metastasis of lung adenocarcinoma through regulating MAPK pathway and associated with immune cells infiltration. A pan-cancer analysis of FAT atypical cadherin 4 (FAT4) in human tumors.
Function and cancer genomics of FAT family genes (review)
FAT4 gene is recurrently mutated in several types of human cancers, such as melanoma, pancreatic cancer, gastric cancer and hepatocellular carcinoma. FAT1 and FAT4 suppress tumor growth via activation of Hippo signaling, whereas FAT1 promotes tumor migration via induction of actin polymerization.
FAT4 FAT atypical cadherin 4 [ (human)] - National Center for ...
Dec 25, 2023 · Increased expression of FAT4 suppress metastasis of lung adenocarcinoma through regulating MAPK pathway and associated with immune cells infiltration. A pan-cancer analysis of FAT atypical cadherin 4 (FAT4) in human tumors. FAT4 identified as a potential modifier of orofacial cleft laterality.
FAT4 protein expression summary - The Human Protein Atlas
A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue resource. "Estimation of protein expression could not be performed. View primary data."
FAT4 regulates the EMT and autophagy in colorectal cancer cells …
Mar 4, 2019 · FAT4 functions as a tumor suppressor, and previous findings have demonstrated that FAT4 can inhibit the epithelial-to-mesenchymal transition (EMT) and the proliferation of gastric cancer cells. However, few studies have investigated the role of FAT4 in the development of colorectal cancer (CRC).
Function and cancer genomics of FAT family genes - PMC
Oct 17, 2012 · FAT4 gene is recurrently mutated in several types of human cancers, such as melanoma, pancreatic cancer, gastric cancer and hepatocellular carcinoma. FAT1 and FAT4 suppress tumor growth via activation of Hippo signaling, whereas FAT1 promotes tumor migration via induction of actin polymerization.
The FAT4 gene provides instructions for making a protein that is found in most tissues. The protein spans the membrane surrounding cells so that part of the protein is outside the cell and part of the protein is inside the cell.
Entry - *612411 - FAT ATYPICAL CADHERIN 4; FAT4 - OMIM
The FAT4 gene encodes a protein that is a member of a large family of protocadherins. DCHS1 ( 603057 ) is another protocadherin that is the ligand for FAT4; FAT4 and DCHS1 form an apically located adhesive complex in the developing brain (summary by Cappello et al., 2013 ).
FAT4 | Cancer Genetics Web - CancerIndex
FAT4 is an upstream regulator that induces YAP1 cytosolic sequestering by phosphorylation (p-Ser 127) and therefore inhibits YAP1-dependent cellular proliferation.
Structure of the planar cell polarity cadherins Fat4 and Dachsous1
Feb 16, 2023 · Here, we determine the co-crystal structure of the human homologs Fat4 and Dachsous1 (Dchs1) to establish the molecular basis for Fat-Dachsous interactions.