Fas signaling pathway involves activating apoptosis (programmed cell death). This happens through the interaction of Fas receptor and Fas ligand. As mentioned, Fas ligand/FasL is a type II transmembrane protein that can exist in both membrane-anchored and soluble forms.

Explore the Fas signaling pathway and find antibodies to detect some of its target proteins, including FasL, Fas, c-FLIP, and caspase 8.

Genetic defects in the Fas - Fas Ligand pathway: lpr mice; Dysregulation of apoptosis, particularly in the Fas - FasL pathway, is considered to be involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE).

Apr 4, 2017 · The precise pathways and unique functions associated with Fas/FasL-mediated signaling in the immune system are known. The dual character of Fas/FasL-mediated immune regulation that induces beneficial or harmful effects is associated with the onset or development of immune disorders.

Mar 1, 2001 · The Fas and FasL pathway provides the key signal to maintain apoptosis. Our data clearly showed that CD69 and B7.2 expression was significantly enhanced before enhancement of Fas expression on LNC shortly after induction of high dose α146–162 peptide tolerance.

Aug 8, 2020 · We demonstrated that the FasL + lung microenvironment eliminates Fas-positive (Fas +) OS cells that metastasize to the lungs, through apoptosis induced by Fas signaling following interaction of Fas on the tumor cell surface with FasL on the lung epithelial cells.

FasL (or agonistic antibodies) reorganizes these complexes and allows the formation of a death-inducing signaling complex (DISC). The Fas DISC contains the adaptor protein Fas-associat-ed death domain protein (FADD) and caspases 8 and 10, which can initiate the process of apopto-sis. FasL-induced clustering of Fas, FADD, and

Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing.

Aug 7, 2014 · FasL engages and trimerizes the death receptor Fas (CD95) on cell surfaces to initiate the extrinsic apoptosis pathway . The Fas-FasL interaction recruits the Fas-associated death domain adapter protein (FADD) via death domain binding, which interacts with dimerized procaspase-8 to form the death-inducing signaling complex (DISC) [4] .

This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: BioCarta. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal