In hemophilia C, you don’t have the clotting factor or blood protein XI, sometimes called factor 11, because you didn’t inherit the F11 gene. Normally, the F11 gene carries instructions on how to create factor XI.

Factor XI (eleven) is a plasma glycoprotein that acts in the contact phase of blood coagulation (the intrinsic pathway). Unlike the other contact factors (high molecular weight kininogen [HMWK], factor XII, and prekallikrein), factor XI is important for normal hemostasis in vivo.

Factor XI, or plasma thromboplastin antecedent, is the zymogen form of factor XIa, one of the enzymes involved in coagulation. Like many other coagulation factors, it is a serine protease . In humans, factor XI is encoded by F11 gene .

Jul 21, 2022 · Factor XI deficiency is a rare, inherited bleeding disorder. XI means “eleven” in Roman numerals. If you have factor XI deficiency, your blood doesn’t clot properly because it lacks certain...

Apr 27, 2022 · Factor XI deficiency is caused by mutations in the F11 gene. The F11 gene encodes factor XI. Factor XI is one of the essential blood proteins and plays a role in aiding the blood to clot. Mutations of the F11 gene result in deficient levels of functional factor XI. The symptoms of factor XI deficiency occur, in part, due to this deficiency.

Most cases of factor XI deficiency are caused by mutations in the F11 gene, which provides instructions for making the factor XI protein. This protein plays a role in the coagulation cascade, which is a series of chemical reactions that forms blood clots in response to injury.

Factor XI (FXI) deficiency, also called hemophilia C, plasma thromboplastin antecedent deficiency and Rosenthal syndrome, was first recognized in 1953 in patients who experienced severe bleeding after dental extractions. Its incidence is estimated …

Factor XI deficiency is caused by a mutation (change) on the F11 gene, which is inherited in an autosomal recessive manner. This means that a person has to inherit the faulty gene from both parents to develop the disease in a severe form.

Oct 15, 2021 · FXI is a homolog of prekallikrein (PK), a component of the plasma kallikrein-kinin system. While sharing structural and functional features with PK, FXI has undergone adaptive changes that allow it to contribute to blood coagulation.

Factor XI deficiency is usually diagnosed because a patient has a family member with the disease. This condition is genetic and passes as a dominant trait, although the rate of mutation is not clearly known.