Two of the main systems that have been used to classify AML into subtypes are the French-American-British (FAB) classification and the newer World Health Organization (WHO) classification.

The French–American–British (FAB) classification systems refers to a series of classifications of hematologic diseases. It is based on the presence of dysmyelopoiesis and the quantification of myeloblasts and erythroblasts .

Oct 27, 2023 · There are 2 staging systems that are commonly used during diagnosis of acute myeloid leukemia (AML). The French-American-British (FAB) classification system is based on morphology to define...

The FAB type (ie, M0-M7) does not provide prognostic information for cases of “AML, NOS” in the 2008 WHO classification. Abstract. The World Health Organization (WHO) classifies acute myeloid leukemia (AML) via genetic, immunophenotypic, biological, and clinical features.

Mar 28, 2013 · The World Health Organization (WHO) classifies acute myeloid leukemia (AML) via genetic, immunophenotypic, biological, and clinical features. Still, "AML, not otherwise specified (NOS)" is further subdivided based on morphologic criteria similar to those of the French-American-British (FAB) classifi …

The reproducibility of FAB classification for acute leukemia was assessed using the modified criteria of the FAB classification. Peripheral smears and bone marrow smears from 36 cases of acute leukemia stained with May-Graunwald-Giemsa were used for this purpose. Cytochemical stains used for this pu …

FAB标准统一了AL在诊断和分型上的混乱，使各家的白血病资料具有可比性，极大地促进了AL的诊断和治疗，至今仍是AL诊断分型的工作基础。 但形态诊断有一定主观性，可重复性仅60%～70%。 将原始细胞≥30%（NEC）定义为AL太过武断。 根据胞质中嗜天青颗粒多少将原始粒细胞分为原粒Ⅰ型和Ⅱ型在实际工作中不易掌握，易有歧义。 AML 伴t（8；21）和M3的患者原始粒细胞比例常低于30%。 除M3临床出血重和早期死亡率高，M7伴有骨髓纤维化，M4和M5常 …

Bone marrow examination invariably reveals replacement of normal marrow elements by lymphoblasts. These may vary as to their morphology in accordance with the French-American-British (FAB) classification (see later).

In leukaemia patients, white blood cell counts can be either elevated or depleted. Bone marrow aspirate and histology are mandatory to establish the diagnosis. FISH, Fluorescent in situ hybridisation. Cytomorphology is a rapid but observer-dependent technique that allows the diagnosis of most AML and MDS cases.

Oct 3, 2023 · In 1976, Dr. John M. Bennett and colleagues, the French-American-British (FAB) cooperative group (Figure 1), published a seminal paper, the first classification of acute myeloid leukemia (AML). 1 Interestingly, for decades it had been recognized that many AML patients experience a preleukemic phase.