FOXL2 - Wikipedia
FOXL2 (OMIM 605597) is a transcription factor belonging to the forkhead box (FOX) superfamily, characterized by the forkhead box/winged-helix DNA-binding domain. FOXL2 plays an important role in ovarian development and function. [6]
FOXL2 gene - MedlinePlus
The FOXL2 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. On the basis of this role, the FOXL2 protein is called a transcription factor.
FOXL2 Gene - GeneCards | FOXL2 Protein | FOXL2 Antibody
Oct 2, 2024 · FOXL2 (Forkhead Box L2) is a Protein Coding gene. Diseases associated with FOXL2 include Blepharophimosis, Ptosis, And Epicanthus Inversus and Premature Ovarian Failure 3. Among its related pathways are Transport of the SLBP independent Mature mRNA and Metabolism of proteins.
FOXL2 : a gene central to ovarian function - PubMed
The FOXL2 (forkhead box L2) gene is located on chromosome 3 and encodes for forkhead box (FOX) family of transcription factors which play a critical role in various biological processes. Germline FOXL2 mutations have been identified in …
FOXL2 directs DNA double-strand break repair pathways by
Apr 24, 2020 · FOXL2 ablation enhances Ku recruitment to DSB sites, imbalances DSB repair kinetics by accelerating NHEJ and inhibiting HR, and thus leads to catastrophic genomic events.
The Genetics and Biology of FOXL2 - PubMed
FOXL2 encodes a transcription factor that regulates a wide array of target genes including those involved in sex development, eyelid development, ovarian function and maintenance, genomic integrity as well as cellular pathways such as cell-cycle progression, proliferation, and apoptosis.
FOXL2 interaction with different binding partners regulates the ...
Mar 22, 2024 · The transcription factor FOXL2 is required in ovarian somatic cells for female fertility. Differential timing of Foxl2 deletion, in embryonic versus adult mouse ovary, leads to distinctive outcomes, suggesting different roles across development.
FOXL2: a gene central to ovarian function - Journal of Clinical …
The FOXL2 (forkhead box L2) gene is located on chromosome 3 and encodes for forkhead box (FOX) family of transcription factors which play a critical role in various biological processes. Germline FOXL2 mutations have been identified in …
668 - Gene ResultFOXL2 forkhead box L2 [ (human)] - National …
Apr 3, 2024 · FOXL2: a gene central to ovarian function. Expanded phenotypic spectrum of FOXL2 Variant c.672_701dup revealed by whole-exome sequencing in a rare blepharophimosis, ptosis, and epicanthus inversus syndrome family. ERK1/2-SOX9/FOXL2 axis regulates ovarian steroidogenesis and favors the follicular-luteal transition.
FOXL2 forkhead box L2 - NIH Genetic Testing Registry (GTR) - NCBI
Feb 12, 2024 · Clinical resource with information about FOXL2, A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population., Blepharophimosis, ptosis, and epicanthus inversus syndrome, Premature ovarian failure 3, and available tests.