Forkhead box C1 - Wikipedia
WEBFOXC1 is a protein encoded by a gene involved in embryonic and ocular development, heart formation, and cancer. Learn about its function, mutations, and clinical significance in this article.
FOXC1: an emerging marker and therapeutic target for cancer
WEBMar 13, 2017 · The Forkhead box C1 (FOXC1) transcription factor is involved in normal embryonic development and regulates the development and function of many organs.
FOXC1 gene - MedlinePlus
WEBThe FOXC1 gene encodes a protein that regulates the activity of other genes and is involved in eye, heart, kidney, and brain development. Learn about the normal function, genetic changes, and health conditions related to the FOXC1 gene.
FOXC1 Gene - GeneCards | FOXC1 Protein | FOXC1 Antibody
WEBAug 6, 2024 · FOXC1 is a transcription factor that regulates various developmental processes, such as eye, bone, kidney and skin formation. Mutations in FOXC1 cause glaucoma and Axenfeld-Rieger syndrome. Learn more about its function, pathways, products, disorders and variants.
FOXC1: an emerging marker and therapeutic target for cancer
WEBJul 7, 2017 · The Forkhead box C1 (FOXC1) transcription factor is involved in normal embryonic development and regulates the development and function of many organs. Most recently, a large body of literature has shown that FOXC1 plays a critical role in tumor development and metastasis.
FOXC1, the new player in the cancer sandbox - PMC - National …
WEBJan 1, 2018 · The FOXC1 gene encodes a transcription factor that is crucial to mesodermal, neural crest, and ocular development, and mutations found in FOXC1 have been found to cause dominantly inherited Axenfeld-Rieger Syndrome (ARS).
WEBFOXC1 is a FOX family member that regulates embryonic development and tumor progression. It is highly expressed in basal-like breast cancer (BLBC), a subtype with poor prognosis, and...
Childhood Glaucoma Genes and Phenotypes: Focus on FOXC1 …
WEBFOXC1, PITX2 and PAX6 are regulatory genes that influence development of the ocular anterior segment including structures involved in glaucoma (Fan and Wiggs, 2010). Loss of function dominant alleles cause clinically evident developmental defects that can include glaucoma (Allen et al., 2015).
Loss of FOXC1 contributes to the corneal epithelial fate switch and ...
WEBJan 8, 2021 · Forkhead box C1 (FOXC1) is required for neural crest and ocular development, and mutations in FOXC1 lead to inherited Axenfeld–Rieger syndrome. Here, we find that FOXC1 and paired box 6 (PAX6...
Therapeutically Targeting Cancers That Overexpress FOXC1: A ...
WEBSep 2, 2021 · FOXC1 is a biomarker and a potential therapeutic target for cancers that overexpress it and have high metastatic risk. This review summarizes the evidence that FOXC1 regulates cancer stem cell traits, partial EMT, invasion, migration, and resistance.