Fibroblast growth factor receptor 2 - Wikipedia
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10. [5] [6] FGFR2 is a receptor for fibroblast growth factor.
FGFR2 Gene - GeneCards | FGFR2 Protein | FGFR2 Antibody
Oct 1, 2024 · FGFR2 (Fibroblast Growth Factor Receptor 2) is a Protein Coding gene. Diseases associated with FGFR2 include Pfeiffer Syndrome and Crouzon Syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.
FGFR: 生长因子受体肿瘤靶向新方向差异化免疫（二） - 知乎
Mar 15, 2021 · kgf家族细胞生长因子和kgfr（fgfr2-iii b）在多种实体瘤高表达，且主要通过fgfr2基因扩增与该信号通路超激活导致肿瘤细胞增殖、生存和emt等，是多种肿瘤较差预后的标志，因此fgfr2-iii b是极有潜力的实体瘤靶点。
FGF/FGFR signaling in health and disease - Nature
Sep 2, 2020 · Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by ...
FGFR2 gene - MedlinePlus
The FGFR2 gene provides instructions for making a protein called fibroblast growth factor receptor 2 (FGFR2). Fibroblast growth factor receptors are related proteins that are involved in important processes such as cell growth and division (proliferation), cell maturation (differentiation), bone development, formation of blood vessels ...
FGFR-targeted therapeutics: clinical activity, mechanisms ...
Feb 29, 2024 · Fibroblast growth factor receptor (FGFR) signalling is aberrantly activated in patients with cancer owing to fusions and/or rearrangements, point mutations or...
FGFR靶向治疗的临床进展 - 知乎 - 知乎专栏
Mar 15, 2024 · FGFR中配体依赖性二聚化或病理改变通过自身抑制机制释放而导致内源性激酶激活。. FGFR激活导致FRS2依赖性激活PI3K–AKT、RAS–ERK和磷脂酶Cγ（PLCγ）依赖性二酰基甘油（DAG）–PKC和IP3–Ca2+信号。. 癌症患者的FGFR改变通过异常的FGFR信号传导促进肿瘤发生：FGFR扩增 ...
FGF2：纷繁复杂的调控因子 - 知乎 - 知乎专栏
Apr 18, 2023 · 成纤维细胞生长因子2 (FGF2)，也称为碱性FGF (bFGF)，是FGF家族中最早被认可的成员之一。. 作为FGFR1、FGFR2、FGFR3和FGFR4的配体，在细胞存活、分裂、分化和迁移的调节中发挥重要作用。. FGF2可诱导血管生成，同时也是组织稳态和癌症中的关键有丝分裂 …
国内首款FGFR抑制剂国内获批|FGFR2|FGFR|抑制剂|胆管癌|生存期
Apr 23, 2022 · 胆管癌患者主要突变基因有KRAS、BRAF、FGFR2、IDH1/2等，其中较为重要的是FGFR2突变。 2022年4月6日，信达生物公司的FGFR 1/2/3抑制剂佩米替尼片（Pemigatinib）已获国家药品监督管理局批准上市，成为国内首款获批上市的FGFR抑制剂。
Truncated FGFR2 is a clinically actionable oncogene in ...
Aug 10, 2022 · Nature - Truncation of exon 18 of FGFR2 (FGFR2ΔE18) is a potent driver mutation in mice and humans, and FGFR-targeted therapy should be considered for patients with cancer expressing stable...