Clinical review: Fresh frozen plasma in massive bleedings - more ...
Jan 28, 2010 · Fresh frozen plasma (FFP) is indicated for the management of massive bleedings. Recent audits suggest physician knowledge of FFP is inadequate and half of the FFP transfused in critical care is inappropriate. Trauma is among the largest consumers of FFP. Current trauma resuscitation guidelines recommend FFP to correct coagulopathy only after diagnosed by …
Clinical effectiveness of fresh frozen plasma compared with …
Oct 14, 2011 · Introduction Haemostatic therapy in surgical and/or massive trauma patients typically involves transfusion of fresh frozen plasma (FFP). Purified human fibrinogen concentrate may offer an alternative to FFP in some instances. In this systematic review, we investigated the current evidence for the use of FFP and fibrinogen concentrate in the perioperative or massive …
Clinical review: Prothrombin complex concentrates - evaluation of ...
Jan 12, 2011 · PCC stands for prothrombin complex concentrates, a product used for emergency reversal of anticoagulation. This article reviews the safety and thrombogenicity of PCCs, and compares them with fresh frozen plasma.
A national study of plasma use in critical care: clinical indications ...
Apr 5, 2011 · Introduction Fresh frozen plasma (FFP) is widely used, but few studies have described patterns of plasma use in critical care. We carried out a multicentre study of coagulopathy in intensive care units (ICUs) and here describe overall FFP utilisation in adult critical care, the indications for transfusions, factors indicating the doses used and the effects …
Pre-hospital plasma transfusion: a valuable coagulation support or …
Jul 1, 2019 · Both measures could have contributed to the higher mortality in the standard care group in PAMPer. The transfusion trigger, however, remains unknown. For COMBAT, the authors admitted that median fibrinogen levels and other coagulation factors on hospital arrival were within reference ranges; and slightly higher in the standard of care non-FFP ...
Effect of transfusion of fresh frozen plasma on parameters of ...
Dec 1, 2015 · Introduction Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion. Furthermore, FFP …
Transfusion in trauma: thromboelastometry-guided coagulation …
Mar 4, 2011 · Introduction Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or platelet concentrate, compared with fresh frozen plasma (FFP)-based haemostatic therapy. Methods This retrospective analysis compared …
Prothrombin complex concentrate (PCC) for treatment of trauma …
Nov 2, 2023 · Currently, standard component therapy for TIC involves administering tranexamic acid , fresh frozen plasma (FFP), and supplemental fibrinogen and calcium . Prothrombin complex concentrates (PCCs) have been proposed for the management of major bleeding and coagulopathy after trauma, particularity when used in conjunction with fibrinogen ...
Effect of therapeutic plasma exchange on antimicrobials in …
Aug 28, 2024 · Therapeutic plasma exchange (TPE) is a procedure in which plasma is separated from the cellular components of whole blood by various methods. The removed plasma is replaced with albumin or fresh frozen plasma (FFP). TPE aims to eliminate disease-related pathogens . Removal of significant amounts of plasma during TPE can alter the ...
Impact of platelet transfusion on outcomes in trauma patients
Feb 21, 2022 · Second, low thresholds expose to dilution: in the case of massive RBC and FFP transfusion without platelet transfusion, platelet count will decrease during the course of trauma resuscitation. In a model of major surgery, a blood loss of one blood volume replaced with RBC and colloids led to decreased platelet count by half, with a large ...