Sep 15, 2023 · Downstream effect of endoplasmic reticulum stress. ER stress activates all UPR signaling pathways, including protective and pro-apoptosis pathways.

Specific ER stress signalling pathways, collectively known as the unfolded protein response (UPR), are required for maintaining ER homeostasis. The UPR is triggered when ER protein …

Here, we discuss the mechanisms of PERK and IRE1 activation and describe two working models for ER stress initiation: the BiP-dependent model and the ligand-driven model. ER stress …

Recent evidence indicates that the UPR is critical in multiple systems, such as cell differentiation, proliferation, immune response, and cell maintenance.

The endoplasmic reticulum (ER) stress response is a cytoprotective mechanism that maintains homeostasis of the ER by upregulating the capacity of the ER in accordance with cellular …

The endoplasmic reticulum (ER) is the largest organelle, serving as a primary site for the synthesis of secreted and membrane-bound proteins. It contacts with various other organelles …

Specific ER stress signalling pathways, collectively known as the unfolded protein response (UPR), are required for maintaining ER homeostasis. The UPR is triggered when ER protein …

Endoplasmic reticulum stress (ER stress) is tightly related to the pathogenesis of both Type 1 and 2 diabetes [57]. A series of factors can induce ER stress, including nutrient deprivation, viral …

Aug 1, 2006 · Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β

Endoplasmic Reticulum Stress Pathway The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins. Stringent quality control ensures that only …