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[ syll. e-kyn, ek-yn] The baby boy name Ekyn is pronounced EH KihN †. Ekyn's origin is African-Nigeria. Ekyn is a derivative of the name Ekon. Ekyn is infrequently used as a baby name for boys. It is not ranked within the top 1000 names.

This model, termed “EKyn”, highlights the impact of elevated KYNA levels during the last week of gestation in rodent development as a sensitive period that impacts molecular, biochemical, and behavioral phenotypes in adulthood.

Mar 31, 2023 · Employing the embryonic kynurenine (EKyn) paradigm to elevate fetal brain KYNA, we presently examined pharmacological inhibition of KAT II to reduce KYNA in adulthood to improve sleep quality.

Mar 31, 2023 · We hypothesize that elevated KYNA, an inhibitor of glutamatergic and cholinergic neurotransmission, contributes to sleep dysfunction. Employing the embryonic kynurenine (EKyn) paradigm to elevate fetal brain KYNA, we presently examined pharmacological inhibition of KAT II to reduce KYNA in adulthood to improve sleep quality.

The KYNA precursor kynurenine was added daily to wet mash fed to (1) dams (100 mg/day; control: ECon; kynurenine-treated: EKyn) or (2) adolescent rats (300 mg/kg/day; control: AdCon; kynurenine-treated: AdKyn).

EKYN animals showed a significant reduction in α7nAChR expression at PD2, a trend which continued into adulthood. This initial decrease, and its persistence, may have interfered with the development of excitatory/inhibitory balance in the PFC.