Drosha - Wikipedia
Drosha is a Class 2 ribonuclease III enzyme [5] that in humans is encoded by the DROSHA (formerly RNASEN) gene. [6][7][8] It is the primary nuclease that executes the initiation step of miRNA processing in the nucleus. It works closely with DGCR8 and in correlation with Dicer.
Drosha drives the formation of DNA:RNA hybrids around DNA
Feb 7, 2018 · Drosha is required within minutes of break induction, suggesting a central and early role for RNA processing in DNA repair. Sequencing of DNA:RNA hybrids reveals RNA invasion around DNA break ...
Drosha - an overview | ScienceDirect Topics
Drosha is the catalytic center of the microprocessor and has two RNase-III domains that make up a catalytic site with each domain making one of the two cuts necessary to excise the pre-miRNA. Drosha excises the pre-miRNA from the pri-miRNA by cutting at the base of the dsRNA stem–loop of the pre-miRNA [82].
Drosha and Dicer: Slicers cut from the same cloth | Cell …
Apr 29, 2016 · Cell Research - DROSHA and its partner DGCR8 form a heterotrimeric complex named Microprocessor, which is essential for microRNA biogenesis. A recent study by Kwon et al. in Cell reveals the...
Structure of Human DROSHA - Cell Press
Jan 14, 2016 · The heretofore-elusive structure of DROSHA provides insights into how nascent microRNAs are recognized and cleaved in their initial processing step and reveals an unexpected similarity between DROSHA and DICER, the enzyme …
The RNase III enzyme DROSHA is essential for microRNA ... - PubMed
Jul 20, 2012 · DROSHA is a nuclear RNase III enzyme responsible for cleaving primary microRNAs (miRNAs) into precursor miRNAs and thus is essential for the biogenesis of canonical miRNAs.
The conserved single-cleavage mechanism of animal DROSHA …
Nov 25, 2021 · We recently discovered that a human RNase III, DROSHA, exhibits a single cleavage on the one strand of primary microRNAs (pri-miRNAs).
DROSHA Gene - GeneCards | RNC Protein | RNC Antibody
Oct 1, 2024 · DROSHA (Drosha Ribonuclease III) is a Protein Coding gene. Diseases associated with DROSHA include Hereditary Breast Ovarian Cancer Syndrome and Lynch Syndrome 5. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and Translational Control.
The RNase III Enzyme DROSHA Is Essential for MicroRNA …
DROSHA is a nuclear RNase III enzyme responsible for cleaving primary microRNAs (miRNAs) into precursor miRNAs and thus is essential for the biogenesis of canonical miRNAs.
Structure of Human DROSHA - ScienceDirect
Jan 14, 2016 · MicroRNA maturation is initiated by RNase III DROSHA that cleaves the stem loop of primary microRNA. DROSHA functions together with its cofactor DGCR8 in a heterotrimeric complex known as Microprocessor. Here, we report the X-ray structure of DROSHA in complex with the C-terminal helix of DGCR8.