DaT (I-123 Ioflupane) scan is the most definitive diagnostic imaging tool for Parkinsonism, identifying dopaminergic neuron loss in Parkinsonism syndrome, including parkinson disease, multisystem atrophy (MSA), progressive supranuclear palsy (PSP...

Nov 8, 2023 · Ioflupane (I-123) is a radiopharmaceutical for the diagnosis of Parkinson disease and its differential diagnoses, e.g. essential tremor versus tremor due to parkinsonian syndromes (idiopathic Parkinson disease, multiple system atrophy and progres...

Feb 17, 2025 · Parkinson disease (PD), also known as idiopathic Parkinson disease (iPD), is a neurodegenerative disease and movement disorder characterized by bradykinesia, rigidity and resting tremor due to progressive degeneration of dopaminergic neurons in t...

Dopamine transporter (DaT) 123I–FP-CIT scans most commonly are interpreted visually. Alternatively, absolute quantitation of radiopharmaceutical uptake may improve scan accuracy. However, neither approach accomodates dependence of striatal uptake on ...

Jan 18, 2024 · Dopamine transporter imaging can be used to distinguish parkinsonian syndromes from other clinical mimics, and it is essential for the radiologist or nuclear medicine physician to carefully review ...

Normal Scan DaTscan images are interpreted visually, based on the appearance of the striata. [123I] ioflupane binds tightly to the DaT in the brain and allows visualization of striatal DaT.

A Society of Nuclear Medicine guideline addressing the indications, technical aspects, interpretation and reporting of DaT SPECT scans with 123-ioflupane (‘DaTSCAN’).

Jan 1, 2012 · Conversely, DaT concentrations will generally be normal in parkinsonism without presynaptic dopaminergic loss, which includes essential tremor, drug-induced parkinsonism, and psychogenic parkinsonism. And in contrast to dementia with Lewy bodies, DaT concentrations are usually normal in Alzheimer's disease (3 – 18).

A DAT brain scan is a nuclear medicine test that looks at the function of dopamine transporters in your brain. It is often used to help distinguish Parkinson’s disease from other causes of tremor or difficulties with movement.

Apr 17, 2019 · The addition of DAT scan quantification allows readers with limited experience in the interpretation of DAT scans to have diagnostic accuracy equivalent to that of experienced readers, while offering an increase in reader confidence.