DNA Damage and DNA Repair: Types and Mechanism - Microbe …
Sep 8, 2023 · Single-stranded breaks (SSBs) in DNA can occur due to oxidative damage, abasic sites, or errors in the activity of the DNA topoisomerase enzyme. These breaks can disrupt DNA replication, halt transcription, and activate cellular processes that can lead to cell death.
Study reveals regions where harmful DNA breaks are most likely …
Aug 2, 2018 · Center for Cancer Research investigators have discovered that double-strand DNA breaks—the most dangerous form of DNA damage, which can lead to cancer—tend to occur during DNA replication at regions known as poly(dA:dT) tracts.
Double-Strand DNA Breaks | Learn Science at Scitable - Nature
The result is double-strand breaks (DSBs) in the chromosome. A DSB can also be caused by environmental exposure to irradiation, other chemical agents, or ultraviolet light (UV).
The Mechanism of Double-Strand DNA Break Repair by the …
Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous recombination and nonhomologous DNA end joining (NHEJ). The diverse causes of DSBs result in a diverse chemistry of …
Studying DNA Double-Strand Break Repair: An Ever-Growing …
DNA double-strand breaks (DSBs) are the most cytotoxic DNA lesions. Their detection, signaling, and repair require a comprehensive cellular response collectively known as the DNA damage response (DDR).
DNA double-strand break signaling and human disorders
Nov 5, 2010 · Homologous recombination and non-homologous end-joining pathways are the two major DNA repair pathways responsible for mediating the repair of DNA double-strand breaks. The signaling of DNA double-strand breaks is critical for cells to orchestrate the repair pathways and maintain genomic integrity.
Double-strand DNA breaks - Latest research and news - Nature
Nov 1, 2024 · A double-strand DNA break (DSB) occurs or arises when both strands of the DNA duplex are severed, often as the result of ionizing radiation. They are particularly deleterious as the DNA ends...
Double‐strand DNA break repair: molecular mechanisms and …
DNA double-strand breaks (DSBs) are the most serious molecular damaging events that endanger the integrity of the genome and the survival of cells. The two primary methods for DSB repair are homologous recombination (HR) and nonhomologous end joining (NHEJ).
Delayed DNA break repair for genome stability - Nature
Oct 6, 2021 · Classical homologous recombination repairs DNA double-strand breaks that arise in replicated DNA loci; the DNA break leads to the formation of two DNA ends, both of which have homology to...
Structure and repair of replication-coupled DNA breaks | Science
Jun 20, 2024 · Tens of thousands of single-strand DNA breaks arise spontaneously in each of our cells each day, representing one of the most common forms of endogenous DNA damage. If these lesions persist, they can potentially collapse incoming replication forks, resulting in lethal double-strand breaks (DSBs).
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