KRAS codon 12 and 13 mutations in relation to disease-free …
KRAS mutations in codon 12 (multivariate HR 1.52; 95% confidence interval [CI] 1.28–1.80; P<.0001) or codon 13 (multivariate HR 1.36; 95% CI 1.04–1.77; P=.0248) were significantly …
A comprehensive survey of Ras mutations in cancer - PMC
Mutations at codon 61 recapitulate the heterogeneity evident between isoforms at codon 12. These data reveal that Ras isoforms exhibit differential and preferential coupling to specific …
Specific mutations in KRAS codon 12 are associated with worse …
Patients with KRAS codon 12 mutations had worse overall survival (HR 1.76 (95% CI 1.27–2.43), P =0.001). Among the five most common codon 12 mutations, only p.G12C (HR 2.21 …
Specific mutations in KRAS codon 12 are associated with worse …
Feb 16, 2017 · Patients with KRAS codon 12 mutations had worse overall survival (HR 1.76 (95% CI 1.27–2.43), P =0.001). Among the five most common codon 12 mutations, only p.G12C …
The current understanding on the impact of KRAS on colorectal …
Aug 1, 2021 · Compared with wild-type KRAS and codon 12 mutant, patients with KRAS mutations at codon 13 are more likely to have metastasis to more than 2 organs, with higher …
KRAS Codon 12 Mutation is Associated with More Aggressive ... - PubMed
Dec 8, 2020 · After stratification, KRAS codon 12 mutation, but not codon 13 mutation, was remarkably associated with peritoneal metastasis, liver-peritoneum metastases, and multi …
KRAS codon 12 and 13 mutations in relation to disease-free ... - PubMed
Jun 1, 2014 · KRAS codon 12 mutations were independently associated with proficient mismatch repair (P < 0.0001), proximal tumor site (P < 0.0001), low grade, age, and sex, whereas codon …
Effect of KRAS codon 12 or 13 mutations on survival with
Methods: We undertook a meta-analysis of three randomized, placebo-controlled trials (RECOURSE, TERRA and J003) to investigate the impact of KRAS mutations in codons 12 or …
Comparative analysis of KRAS codon 12, 13, 18, 61 and 117
Feb 23, 2015 · KRAS mutations occur in one third of human cancers and cluster in several hotspots, with codons 12 and 13 being most commonly affected. It has been suggested that …
KRAS Codons 12 and 13 Mutation Analysis: A Comparative Study …
Jan 4, 2012 · Seven mutations in codons 12 and 13 of KRAS (95% of the observed human mutations) preclude the efficacy of anti-EGFR therapy for the treatment of CRC. Assessment …