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  1. Nature
    https://www.nature.com/articles/gene201529

    Mouse Cd59b but not Cd59a is upregulated to protect …

    • Universally expressed CD59 is the sole membrane complement regulatory protein that protects host cells from complement damage by restricting membrane attack complex assembly. The huma… See more

    Introduction

    The complement system is essential to innate immunity and functions as a key modulator of adaptive immunity.1 Complement activation, regardless of the initiated pat… See more

    Nature
    Results

    NF-ÎşB and SRF regulate mCd59b transcription
    We recently demonstrated that Sp1 is responsible for human CD59 constitutive expression… See more

    Nature
    Discussion

    The complement system, a major component of innate immunity, is an important first-line defense against invading pathogens. It can be subtly tuned physiologic… See more

    Nature
    Materials and methods

    Cell culture and reagents
    The mouse cell lines Hepa 1-6 and NIH/3T3 (Type Culture Collection Cell Bank, Chinese Academy of Sciences) were maintained … See more

    Nature
    Is CD59 a membrane inhibitor of reactive lysis?
    CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. It is an LU domain and belongs to the LY6 / uPAR / alpha-neurotoxin protein family. CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor.
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    Introduction
    Results
    Discussion
    Materials and methods
    Is CD59 a membrane inhibitor of reactive lysis?
     
  1. Studies of Cd59b Cd6
    PubMed
    Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
    Human pancreatic islets highly express CD59, which is a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein and is required for insulin secretion. How cell-surface CD59 could interact with intracellular exocytotic machinery has so far not been described. We now demonstrate the existence...
    Author: Ewelina Golec
    Published: 2022/06/14
    Keywords: CD59; SNA…
    PubMed
    Mouse Cd59b but not Cd59a is upregulated to protect cells from complement attack in response to inflammatory stimulation
    Universally expressed CD59 is the sole membrane complement regulatory protein that protects host cells from complement damage by restricting membrane attack complex assembly. The human gene encodes a single CD59, whereas the mouse gene encodes a duplicated CD59, comprising mCd59a and mCd59b, with di...
    Author: J Chen
    Published: 2015/10
    Keywords: National In…
    National Center for Biotechnology Information
    The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility
    In mouse, genes encoding complement regulators CD55 and CD59 have been duplicated. The first described form of CD59, CD59a, is broadly distributed in mouse tissues, while the later identified CD59b was originally described as testis specific. Subsequent studies have been contradictory, some reportin...
    Author: Rossen M. Do…
    Published: 2008/01
    Publication: Mol Immu…
    National Center for Biotechnology Information
    Molecular pathogenesis of human CD59 deficiency
    Objective To characterize all 4 mutations described for CD59 congenital deficiency. Methods The 4 mutations, p.Cys64Tyr, p.Asp24Val, p.Asp24Valfs*, and p.Ala16Alafs*, were described in 13 individuals with CD59 malfunction. All 13 presented with recurrent Guillain-Barré syndrome or chronic inf...
    Author: Netanel Karbia…
    Published: 2018/12
    Publication: Neurol Ge…
    ScienceDirect
    Alternative roles for CD59 - ScienceDirect
    CD59 was first identified as a regulator of the terminal pathway of complement, which acts by binding to the C8/C9 components of the assembling membrane attack complex (MAC), to inhibit formation of the lytic pore. Structurally, CD59 is a small, highly glycosylated, GPI-linked protein, with a wide e...
    Published: 2007/01/01
    Cited By: 0
    Keywords: CD59; Co…
    ScienceDirect
    CD59: Biological function and its potential for drug target action
    CD59 is a major inhibitor of membrane attack complex (MAC) formation, which is anchored to the cell membrane by glycosylphosphatidylinositol (GPI). The protein is widely expressed in most human tissues. Several studies have reported the involvement of CD59 with several diseases such as paroxysmal no...
    Published: 2023/06/01
    Cited By: 0
    Keywords: CDC compl…
    ScienceDirect
    CD59 - ScienceDirect
    CD59 is a heavily glycosylated single-chain glycosylphosphatidylinositol (GPI)-anchored membrane protein. It is related to the Ly6/uPAR superfamily of GPI-anchored (usually), cysteine-rich proteins characterised by a conserved disulphide bond pattern that creates the three-fingered Ly6/uPAR domain. ...
    Published: 2018/01/01
    Cited By: 0
    Keywords: CD59 glyco…
  2. PubMed
    https://pubmed.ncbi.nlm.nih.gov/35666870

    Alternative splicing encodes functional intracellular CD59 isoforms ...

  3. PubMed
    https://pubmed.ncbi.nlm.nih.gov/26204229

    Mouse Cd59b but not Cd59a is upregulated to protect cells from ...

  4. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995235

    The mouse complement regulator CD59b is significantly expressed …

  5. Wikipedia
    https://en.wikipedia.org/wiki/CD59

    CD59 - Wikipedia

  6. American Association of Immunologists
    https://journals.aai.org/jimmunol/article/165/5/2528/33185

    Identification and Functional Characterization of a New Gene …

  7. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244018

    Molecular pathogenesis of human CD59 deficiency - PMC

  8. American Association of Immunologists
    https://journals.aai.org/jimmunol/article/1…

    CD59, a Complement Regulatory Protein, Controls …

    Feb 1, 2007 · CD59a is a widely distributed protein, whereas CD59b is expressed only in testis . Thus, CD59a is the primary regulator of MAC in mice ( 17 ). Recently, we have shown that MAC formation via the alternative pathway is …

  9. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0161589006002240

    Alternative roles for CD59 - ScienceDirect

  10. Springer
    https://link.springer.com/article/10.1007/s00335-001-2060-8

    Genomic structure, functional comparison, and tissue distribution …