CD5 includes a scavenger receptor cysteine-rich protein domain. T cells express higher levels of CD5 than B cells. CD5 is upregulated on T cells upon strong activation. In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides.

Patients with CD5-expressing lymphomas presenting with splenomegaly are frequently diagnosed with chronic lymphocytic leukemia. The most important differential diagnosis is mantle cell lymphoma, both in its classical and leukemic, non-nodal forms, given its prognostic and therapeutic implications.

Jul 1, 2020 · CD5 is characteristically expressed in T lymphocytes and is expressed at lower levels in B1 cells, a subset of B cells. B1 cells constitute a large subset in the human fetal spleen and...

We studied patients with CD5+B-CLPD to 1) more completely define the clinical features and pathology of CD5+B-CLPD, 2) compare these features to patients presenting with typical CLL, and 3) test the hypothesis that a subset of patients with CD5+B-CLPD could have a unique B …

The CD5(+) B cell population is prominent in early life and produce low avidity and, thereby, polyreactive antibodies. CD5(+) B cells are receptive to cytokines and interleukin-10 seems to be influential in the regulation of some of these CD5(+) B cells.

Jul 23, 2015 · Monoclonal B lymphocytosis (MBL) is defined as the presence of a clonal B-cell population in the peripheral blood with fewer than 5 × 10 9 /L B-cells and no other signs of a lymphoproliferative disorder. The majority of cases of MBL have the immunophenotype of chronic lymphocytic leukemia (CLL).

Nov 1, 2004 · Although the CD5+ B-cells account for a small percentage of B-cells in healthy adult individuals, their study gathers importance in view of their involvement in autoimmune states, in early lymphoid recovery after bone marrow (BM) transplantation and in malignancies such as the B-CLL and mantle cell lymphoma.

Dec 15, 2002 · Human peripheral blood CD5 + B cells produce more IL-10 than CD5 − B cells after BCR activation. Introducing CD5 into CD5 − B cells induces the production of IL-10 by activating its promoter and the synthesis of its mRNA. The cytoplasmic domain of CD5 is sufficient for this process.

Jul 1, 1999 · The origin of CD5+ B cells remains controversial. The differential response to ligation of CD5 resulting in apoptosis or proliferation provides insight into its roles in distinct human B cells.

Aug 8, 2016 · In this study, we show that CD5 expression activates a number of important signaling pathways, including Erk1/2, leading to IL-10 production through a novel pathway independent of BCR engagement.