CD44 - Wikipedia
CD44 expression is an indicative marker for effector-memory T-cells. Memory cell proliferation (activation) can also be assayed in vitro with CFSE chemical tagging. In addition, variations in CD44 are reported as cell surface markers for some breast and prostate cancer stem cells.
CD44 - an overview | ScienceDirect Topics
CD44 is an acidic cell surface adhesion protein that is broadly expressed, including in the membranes of B cells, granulocytes, monocytes, and erythrocytes as well as on many thymocytes and mature T cells.
CD44 Gene - GeneCards | CD44 Protein | CD44 Antibody
Oct 1, 2024 · CD44 (CD44 Molecule (IN Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include Hematologic Cancer and Lichen Sclerosus. Among its related pathways are Glycosaminoglycan metabolism and Innate Immune System.
CD44: A Multifunctional Cell Surface Adhesion Receptor Is a ... - PubMed
Mar 7, 2017 · CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with appropriate extracellular matrix ligands promotes the migration and …
CD44: From adhesion molecules to signalling regulators
Jan 1, 2003 · The CD44 transmembrane glycoprotein family adds new aspects to these roles by participating in signal-transduction processes — not only by establishing specific transmembrane complexes, but...
The biology and role of CD44 in cancer progression: therapeutic ...
May 10, 2018 · Here, we review current data on the structural and functional properties of CD44, the known roles for CD44 in tumorigencity, the regulation of CD44 expression, and the potential for targeting CD44 for cancer therapy.
CD44: A Multifunctional Cell Surface Adhesion Receptor Is a …
Mar 7, 2017 · CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with appropriate extracellular matrix ligands promotes the migration and …
CD44 is a phagocytic receptor - American Society of Hematology
May 15, 2006 · In this manuscript, we provide evidence that CD44 is a bone fide phagocytic receptor, inasmuch as ligation and clustering of CD44 is sufficient to trigger internalization of large (> 3 μm) particles. In this regard, CD44 is comparable to Fcγ receptors and CR3, the 2 prototypic phagocytic receptors.
The role of CD44 in disease pathophysiology and targeted treatment
CD44 has been implicated in a number of diseases such as cancer, arthritis, interstitial lung disease (ILD), vascular disease, wound healing, and infections by pathogens. CD44–HA signaling has been found be involved in the pathophysiologies of both …
CD44 as a tumor biomarker and therapeutic target - PMC
Dec 10, 2020 · This review aims to encapsulate the structure of CD44 gene and protein, outline the roles which CD44 plays in tumor initiation, progression and therapy-resistance, and also highlight the perspectives for CD44-targeted therapy.