Dec 24, 2024 · CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Cd40 Ligand Deficiency . Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling .

CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type.

The CD40LG gene provides instructions for making a protein called CD40 ligand, which is found on the surface of immune system cells known as T cells. Learn about this gene and related health conditions.

CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity.

Jan 4, 2025 · Title: Respiratory infections in X-linked hyper-IgM syndrome with CD40LG mutation: a case series of seven children in China. Termination of CD40L co-stimulation promotes human B cell differentiation into antibody-secreting cells.

Clinical studies have revealed that circulating levels of soluble CD40L (sCD40L) are associated with renal function in the setting of kidney disease. Levels of the circulating CD40 receptor (sCD40), sCD40L, and local CD40 expression are tightly related to renal injury in different types of kidney disease.

The X-linked gene CD40LG encodes CD40L, a T-cell coactivation receptor expressed under transcriptional control of nuclear factor of activated T-cells (NFAT). 5 CD40L-deficient patients display impaired immunoglobulin class-switching and defective cellular immunity whereas CD40L-overexpressing mice develop high-titer autoantibodies and chronic ...

CD40LG is downregulated in BRCA patients, and a lower CD40LG expression is associated with advanced tumor stages and a poor prognosis. We also reveal that CD40LG involves in a series of immune-related pathways and is associated with multiple …

Feb 8, 2025 · A novel CD40LG deletion causes the hyper-IgM syndrome with normal CD40L expression in a 6-month-old child; Report targeting and liposomal drug delivery of methotrexate to CD40L expressing T cells for treatment of autoimmune diseases.

Gauchat et al. (1993) cloned the cDNA for human CD40 ligand (CD40LG) from a CD4-positive T-cell clone. The cDNA predicts a type II membrane protein of 261 amino acids. Seyama et al. (1996) reported that the CD40LG gene contains 5 exons.