In this review, we discussed the ecological dysbiosis of dental biofilm, their caries-related phenotypes, the current therapeutic targets of cariogenic biofilm, and/or the control of cariogenic biofilm on its pathogenic traits.

Jun 16, 2021 · Here, we summarized the recent advances in modulating cariogenic biofilm and/or controlling its pathogenic traits. Keywords: cariogenic niche; interspecies interactions; pathogenic traits; therapeutic targets.

Recent approaches disrupting the biofilm microbial community and the microenvironment have emerged, including specific targeting of cariogenic pathogens, modulation of biofilm pH, and synergistic combination of bacterial killing and matrix degradation.

A new cross-feeding mechanism mediated by GtfB was found in mixed biofilms of Streptococcus mutans and Candida albicans that can enhance the sugar metabolism level in the mixed biofilms and enhance the cariogenic toxicity of the biofilms [35,36]. Based on the understanding of the dental caries microbiome, dental caries is considered to be a ...

This paper discusses the role of dental biofilm and adjunctive therapies in the management of dental caries. Dental biofilm is a site of bacterial proliferation and growth, in addition to being a location of acid production.

Cariogenic biofilms play important roles in the overall health of patients. The development and proliferation of those biofilms can only occur when the teeth are not properly and frequently cleansed using a toothbrush and toothpaste.

Aug 3, 2021 · Putting all these data together, we give an overview of oral biofilms and active compounds used in modern oral care products to interact with them. The special focus is on inorganic compounds and their interaction with oral biofilms.

May 17, 2021 · In this review, we discussed the ecological dysbiosis of dental biofilm, their caries-related phenotypes, the current therapeutic targets of cariogenic biofilm, and/or the control of cariogenic biofilm on its pathogenic traits.

Apr 19, 2018 · Accordingly, the aim of this study was to investigate the differences in virulence (EPSs and acidogenicity) and viability of cariogenic biofilms according to the direction of substratum surface using an S. mutans biofilm model.

In this study, we discuss the prevention of caries through the inhibition of dental biofilms. The oral biofilm formed by cariogenic (that is, pathogenic) microorganisms is a complex microbial community in the mouth.

Mar 11, 2025 · CFS altered the composition and architecture of the cariogenic biofilm, reducing the abundance of S. mutans and other cariogenic species. It also reduced enamel demineralization, indicating a protective effect against caries. In vitro study; limited generalizability to clinical settings. Srivastava et al. In vitro

Aug 3, 2021 · Oral biofilms will build up within minutes after cleaning of the dental hard tissues. While the application of remineralizing agents is a well-known approach to prevent dental caries, modern...

Dental caries is a biofilm-dependent oral disease caused by infection with cariogenic pathogens, such as Streptococcus mutans, and associated with frequent exposure to a sugar-rich diet and poor oral hygiene.

Feb 8, 2024 · Cariogenic biofilms formed on the tooth surface secrete organic acids and thus result in demineralization. Delving into the depth of biofilms is crucial to understand the pathogenic mechanisms and design improved therapeutic approaches.

Aug 1, 2022 · Dysbiosis of oral microbiota usually caused by the intrusion of external pathogenic microbes results in the formation of biofilm on the dental enamel giving rise to dental plaque. Untreated plaque is followed by the formation of caries.

Thus, the aim of this review is to consider the broad role of sucrose in the cariogenic properties of the biofilm, and to discuss tenable hypotheses to explain the low inorganic ion concentrations found in the matrix of the biofilms formed in the presence of this carbohydrate.

Jan 1, 2023 · This chapter summarizes the role of S. mutans in the development of cariogenic biofilm, molecular basis of cariogenic biofilm formation by S. mutans, as well as the most recent approaches to control and eradicate biofilm-related infections.

Various models exist which explain the transition from a health-compatible oral microbiota to a cariogenic microbiota. Longitudinal studies may increase our knowledge of the oral microbial compositions in different age groups by analyzing the temporal sequence leading to …

Sep 1, 2022 · In this review, we summarize strategies for dispersion of cariogenic biofilms, including biofilm environment, signaling pathways, biological therapies, and nanovehicle-based adjuvant strategies. The mechanisms behind these strategies have been discussed from the components of oral biofilm.

This study aimed to assess the presence of potentially cariogenic microorganisms in human teeth biofilm. The microorganisms were isolated from human mouth and freshly extracted human maxillary incisors extracted for reasons of caries.

Cariogenic biofilms are highly structured microbial communities embedded in an extracellular matrix, a multifunctional scaffold that is essential for the existence of the biofilm lifestyle and full expression of virulence.

Mar 9, 2025 · One of the primary culprits behind this condition is the colonization of teeth by cariogenic bacteria, notably Streptococcus mutans, which can be transmitted from mother to baby in early life . ... For instance, IgY targeting bacterial …