CYP2D6 - Wikipedia
WEBCytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra.
A Review of the Important Role of CYP2D6 in Pharmacogenomics
WEBOct 30, 2020 · Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of ~20% of commonly used drugs across a broad spectrum of medical disciplines including psychiatry, pain management, oncology and cardiology.
CYP2D6 Overview: Allele and Phenotype Frequencies
WEBOct 15, 2021 · The purpose of this document is to provide a centralized resource for key information on the CYP2D6 gene, allele function, and phenotype prediction, as well as an overview of the recent literature reporting the allele and phenotype frequencies.
Get to Know an Enzyme: CYP2D6 - Pharmacy Times
WEBJul 1, 2008 · Get to Know an Enzyme: CYP2D6. Author (s): John R. Horn, PharmD, FCCP Philip D. Hansten, PharmD. The enzyme CYP2D6 affects the metabolism of many drugs, and its effect is altered by genetic variability.
CYP2D6 - an overview | ScienceDirect Topics
WEBOct 28, 2020 · CYP2D6 is an enzyme from the cytochrome p450 superfamily involved in the metabolism of about 25% of commonly prescribed drugs. These include tamoxifen, beta-receptor blockers, analgesics, anticonvulsants, antidepressants and anti-psychotics, antihypertensives, and norepinephrine reuptake inhibitors.
Molecular genetics of CYP2D6: Clinical relevance with focus ...
WEBThe CYP2D6 enzyme catalyses the metabolism of a large number of clinically important drugs including antidepressants, neuroleptics, some antiarrhythmics, lipophilic β-adrenoceptor blockers and opioids.
CYP2D6: The Gene That Plays A Major Role In Drug Metabolism
WEBMay 12, 2023 · The CYP2D6 enzyme, found mostly in the liver and brain, is responsible for the metabolism of commonly prescribed drugs such as antidepressants, antipsychotics, beta-blockers, opioids, and antiarrhythmic medications.