CYP2C9 - Wikipedia
Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein. The enzyme is involved in the metabolism, by oxidation, of both xenobiotics, including drugs, and endogenous compounds, including fatty acids. In humans, the …
CYP2C9 gene - MedlinePlus
The CYP2C9 gene provides instructions for making an enzyme that is found in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport. The CYP2C9 enzyme breaks down (metabolizes) compounds including steroid hormones and …
CYP2C9 - an overview | ScienceDirect Topics
Aug 15, 2018 · The cytochrome P450 2C9 (CYP2C9) is a member of the CYP2C subfamily of the cytochrome P450 enzymes and is the major metabolizing enzyme for S -warfarin and several other widely prescribed medications.
Cytochrome P4502C9: an enzyme of major importance in human ...
Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug metabolizing enzymes in humans. Substrates for CYP2C9 include fluoxetine, losartan, phenytoin, tolbutamide, torsemide, S-warfarin, and numerous NSAIDs. …
Cytochrome P450 2C9-CYP2C9 - PMC - PubMed Central (PMC)
CYP2C9 is the enzyme responsible for the metabolism of the S-isomer of warfarin that is principally responsible for the anticoagulant effect of the drug. The crystal structure of human CYP2C9 was described by Williams et al. [46], for both CYP2C9 in complex with warfarin and unliganded CYP2C9 (Protein Data Bank ID: 1OG2 and 1OG5, respectively).
PharmVar GeneFocus: CYP2C9 - PMC - PubMed Central (PMC)
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the CYP2C9 gene locus impacts the metabolism or bioactivation of many clinically important drugs ...
Impact of genetic and non-genetic factors on hepatic CYP2C9 ...
Aug 24, 2021 · CYP2C9, one of the most abundant hepatic cytochrome P450 enzymes, is involved in metabolism of 15–20% of clinically important drugs (warfarin, sulfonylureas, phenytoin, non-steroid...
CYP2C9 cytochrome P450 family 2 subfamily C member 9 [ (human)]
Oct 28, 2024 · This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
The genetic landscape of major drug metabolizing cytochrome ...
Sep 6, 2022 · Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple CYP variants constitute clinically relevant biomarkers for the guidance of drug selection and dosing. We...