Atypical chemokine receptor 3 also known as C-X-C chemokine receptor type 7 (CXCR-7) and G-protein coupled receptor 159 (GPR159) is a protein that in humans is encoded by the ACKR3 …

Feb 9, 2023 · ACKR3 (Atypical Chemokine Receptor 3), traditionally called CXCR7, is up-regulated in many cancers, including advanced prostate cancer, and represents promising …

The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors (GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They play a key role …

Jun 21, 2018 · Chemokine receptors are the target of small peptide chemokines. They play various important roles in physiological and pathological processes. CXCR7, later renamed …

Apr 14, 2021 · In neuroblastoma, CXCR4 and CXCR7 expression are different or even opposed, as CXCR7 is observed in neural-associated compartment of differentiated and matured tumors …

CXCR7 is a receptor that binds to SDF-1 and I-TAC, highly expressed on malignant cells compared to normal tissues, playing a role in signal transduction and heart development, and …

Dec 7, 2020 · Multiple small molecules targeting CXCR4/CXCR7 have been developed and used for preclinical and clinical cancer treatment. In this review, we describe the roles of the …

Aug 1, 2023 · CXCR7 is an atypical chemokine receptor that recruits β-arrestin (ARRB2) and internalizes into clathrin-coated intracellular vesicles where the complex acts as a scaffold for …

An initial study showed a high expression of CXCR7 in human T-lymphocytes , supported by our data of high CXCR7 gene expression in bone marrow and lymphoblasts of T-ALL patients, T …

Nov 23, 2020 · This study demonstrates that SDF-1α-stimulated CXCR7 mediates β-arrestin2 recruitment via different molecular networking from that of CXCR4. CXCR7 may be neither a …